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Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo.
Silvestre RN, Eitler J, de Azevedo JTC, Tirapelle MC, Fantacini DMC, de Souza LEB, Swiech K, Covas DT, Calado RT, Montero PO, Malmegrim KCR, Figueiredo ML, Tonn T, Picanço-Castro V. Silvestre RN, et al. Among authors: tonn t. Front Immunol. 2023 Sep 25;14:1226518. doi: 10.3389/fimmu.2023.1226518. eCollection 2023. Front Immunol. 2023. PMID: 37818365 Free PMC article.
ErbB2 (HER2)-CAR-NK-92 cells for enhanced immunotherapy of metastatic fusion-driven alveolar rhabdomyosarcoma.
Heim C, Moser LM, Kreyenberg H, Bonig HB, Tonn T, Wels WS, Gradhand E, Ullrich E, Meister MT, Koerkamp MG, Holstege FCP, Drost J, Klusmann JH, Bader P, Merker M, Rettinger E. Heim C, et al. Among authors: tonn t. Front Immunol. 2023 Aug 18;14:1228894. doi: 10.3389/fimmu.2023.1228894. eCollection 2023. Front Immunol. 2023. PMID: 37662907 Free PMC article.
Palbociclib impairs the proliferative capacity of activated T cells while retaining their cytotoxic efficacy.
Arndt C, Tunger A, Wehner R, Rothe R, Kourtellari E, Luttosch S, Hannemann K, Koristka S, Loureiro LR, Feldmann A, Tonn T, Link T, Kuhlmann JD, Wimberger P, Bachmann MP, Schmitz M. Arndt C, et al. Among authors: tonn t. Front Pharmacol. 2023 Feb 3;14:970457. doi: 10.3389/fphar.2023.970457. eCollection 2023. Front Pharmacol. 2023. PMID: 36817127 Free PMC article.
Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma.
Burger MC, Forster MT, Romanski A, Straßheimer F, Macas J, Zeiner PS, Steidl E, Herkt S, Weber KJ, Schupp J, Lun JH, Strecker MI, Wlotzka K, Cakmak P, Opitz C, George R, Mildenberger IC, Nowakowska P, Zhang C, Röder J, Müller E, Ihrig K, Langen KJ, Rieger MA, Herrmann E, Bonig H, Harter PN, Reiss Y, Hattingen E, Rödel F, Plate KH, Tonn T, Senft C, Steinbach JP, Wels WS. Burger MC, et al. Among authors: tonn t. Neuro Oncol. 2023 Nov 2;25(11):2058-2071. doi: 10.1093/neuonc/noad087. Neuro Oncol. 2023. PMID: 37148198 Free PMC article.
Bortezomib promotes the TRAIL-mediated killing of resistant rhabdomyosarcoma by ErbB2/Her2-targeted CAR-NK-92 cells via DR5 upregulation.
Heim C, Hartig L, Weinelt N, Moser LM, Salzmann-Manrique E, Merker M, Wels WS, Tonn T, Bader P, Klusmann JH, van Wijk SJL, Rettinger E. Heim C, et al. Among authors: tonn t. Mol Ther Oncol. 2024 Apr 11;32(2):200802. doi: 10.1016/j.omton.2024.200802. eCollection 2024 Jun 20. Mol Ther Oncol. 2024. PMID: 38706988 Free PMC article.
OECD workshop consensus report: Ethical considerations with respect to human derived products, specifically human serum, in OECD test guidelines.
Jacobs MN, Bult JM, Cavanagh K, Chesne C, Delrue N, Fu J, Grange E, Langezaal I, Misztela D, Murray J, Paparella M, Stoddart G, Tonn T, Treasure C, Tsukano M, Versteegen R. Jacobs MN, et al. Among authors: tonn t. Front Toxicol. 2023 Feb 27;5:1140698. doi: 10.3389/ftox.2023.1140698. eCollection 2023. Front Toxicol. 2023. PMID: 36923365 Free PMC article.
161 results