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Neutral ceramidase-active site inhibitor chemotypes and binding modes.
Coant N, Bickel JD, Rahaim R, Otsuka Y, Choi YM, Xu R, Simoes M, Cariello C, Mao C, Saied EM, Arenz C, Spicer TP, Bannister TD, Tonge PJ, Airola MV, Scampavia L, Hannun YA, Rizzo RC, Haley JD. Coant N, et al. Among authors: tonge pj. Bioorg Chem. 2023 Oct;139:106747. doi: 10.1016/j.bioorg.2023.106747. Epub 2023 Jul 27. Bioorg Chem. 2023. PMID: 37531819 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 36783605
Elucidating the Signal Transduction Mechanism of the Blue-Light-Regulated Photoreceptor YtvA: From Photoactivation to Downstream Regulation.
He Y, Collado JT, Iuliano JN, Woroniecka HA, Hall CR, Gil AA, Laptenok SP, Greetham GM, Illarionov B, Bacher A, Fischer M, French JB, Lukacs A, Meech SR, Tonge PJ. He Y, et al. Among authors: tonge pj. ACS Chem Biol. 2024 Mar 15;19(3):696-706. doi: 10.1021/acschembio.3c00722. Epub 2024 Feb 22. ACS Chem Biol. 2024. PMID: 38385342 Free PMC article.
Single Amino Acid Mutation Decouples Photochemistry of the BLUF Domain from the Enzymatic Function of OaPAC and Drives the Enzyme to a Switched-on State.
Tolentino Collado J, Bodis E, Pasitka J, Szucs M, Fekete Z, Kis-Bicskei N, Telek E, Pozsonyi K, Kapetanaki SM, Greetham G, Tonge PJ, Meech SR, Lukacs A. Tolentino Collado J, et al. Among authors: tonge pj. J Mol Biol. 2024 Mar 1;436(5):168312. doi: 10.1016/j.jmb.2023.168312. Epub 2023 Oct 10. J Mol Biol. 2024. PMID: 37827329 Free article.
High Accuracy Prediction of PROTAC Complex Structures.
Ignatov M, Jindal A, Kotelnikov S, Beglov D, Posternak G, Tang X, Maisonneuve P, Poda G, Batey RA, Sicheri F, Whitty A, Tonge PJ, Vajda S, Kozakov D. Ignatov M, et al. Among authors: tonge pj. J Am Chem Soc. 2023 Apr 5;145(13):7123-7135. doi: 10.1021/jacs.2c09387. Epub 2023 Mar 24. J Am Chem Soc. 2023. PMID: 36961978 Free PMC article.
Synthesis and Preclinical Evaluation of a Novel Fluorine-18-Labeled Tracer for Positron Emission Tomography Imaging of Bruton's Tyrosine Kinase.
Li K, Wang M, Akoglu M, Pollard AC, Klecker JB, Alfonso P, Corrionero A, Prendiville N, Qu W, Parker MFL, Turkman N, Cohen JA, Tonge PJ. Li K, et al. Among authors: tonge pj. ACS Pharmacol Transl Sci. 2023 Feb 10;6(3):410-421. doi: 10.1021/acsptsci.2c00215. eCollection 2023 Mar 10. ACS Pharmacol Transl Sci. 2023. PMID: 36926452 Free PMC article.
179 results