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A conformational switch driven by phosphorylation regulates the activity of the evolutionarily conserved SNARE Ykt6.
McGrath K, Agarwal S, Tonelli M, Dergai M, Gaeta AL, Shum AK, Lacoste J, Zhang Y, Wen W, Chung D, Wiersum G, Shevade A, Zaichick S, van Rossum DB, Shuvalova L, Savas JN, Kuchin S, Taipale M, Caldwell KA, Caldwell GA, Fasshauer D, Caraveo G. McGrath K, et al. Among authors: tonelli m. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2016730118. doi: 10.1073/pnas.2016730118. Proc Natl Acad Sci U S A. 2021. PMID: 33723042 Free PMC article.
Protein conformational dynamics in the mechanism of HIV-1 protease catalysis.
Torbeev VY, Raghuraman H, Hamelberg D, Tonelli M, Westler WM, Perozo E, Kent SB. Torbeev VY, et al. Among authors: tonelli m. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20982-7. doi: 10.1073/pnas.1111202108. Epub 2011 Dec 8. Proc Natl Acad Sci U S A. 2011. PMID: 22158985 Free PMC article.
pH-induced conformational change of IscU at low pH correlates with protonation/deprotonation of two conserved histidine residues.
Dai Z, Kim JH, Tonelli M, Ali IK, Markley JL. Dai Z, et al. Among authors: tonelli m. Biochemistry. 2014 Aug 19;53(32):5290-7. doi: 10.1021/bi500313t. Epub 2014 Aug 4. Biochemistry. 2014. PMID: 25055301 Free PMC article.
Dai Z., Tonelli, M., and Markley, J. L. (2012) Biochemistry, 51, 9595-9602. Cai, K., Frederick, R. O., Kim, J. H., Reinen, N. M., Tonelli, M., and Markley, J. L. (2013) J. Biol. Chem., 288, 28755-28770]. ...
Dai Z., Tonelli, M., and Markley, J. L. (2012) Biochemistry, 51, 9595-9602. Cai, K., Frederick, R. O., Kim, J. H., Reinen, N. …
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane.
Van QN, López CA, Tonelli M, Taylor T, Niu B, Stanley CB, Bhowmik D, Tran TH, Frank PH, Messing S, Alexander P, Scott D, Ye X, Drew M, Chertov O, Lösche M, Ramanathan A, Gross ML, Hengartner NW, Westler WM, Markley JL, Simanshu DK, Nissley DV, Gillette WK, Esposito D, McCormick F, Gnanakaran S, Heinrich F, Stephen AG. Van QN, et al. Among authors: tonelli m. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24258-24268. doi: 10.1073/pnas.2006504117. Epub 2020 Sep 10. Proc Natl Acad Sci U S A. 2020. PMID: 32913056 Free PMC article.
1,318 results