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The cytotoxic effect of α-tomatine in MCF-7 human adenocarcinoma breast cancer cells depends on its interaction with cholesterol in incubation media and does not involve apoptosis induction.
Sucha L, Hroch M, Rezacova M, Rudolf E, Havelek R, Sispera L, Cmielova J, Kohlerova R, Bezrouk A, Tomsik P. Sucha L, et al. Among authors: tomsik p. Oncol Rep. 2013 Dec;30(6):2593-602. doi: 10.3892/or.2013.2778. Epub 2013 Oct 2. Oncol Rep. 2013. PMID: 24100733 Free PMC article.
Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice.
Havelek R, Muthna D, Tomsik P, Kralovec K, Seifrtova M, Cahlikova L, Hostalkova A, Safratova M, Perwein M, Cermakova E, Rezacova M. Havelek R, et al. Among authors: tomsik p. Chem Biol Interact. 2017 Sep 25;275:121-132. doi: 10.1016/j.cbi.2017.07.018. Epub 2017 Jul 26. Chem Biol Interact. 2017. PMID: 28756149
The anticancer activity of alpha-tomatine against mammary adenocarcinoma in mice.
Tomsik P, Micuda S, Sucha L, Cermakova E, Suba P, Zivny P, Mazurova Y, Knizek J, Niang M, Rezacova M. Tomsik P, et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013 Jun;157(2):153-61. doi: 10.5507/bp.2013.031. Epub 2013 May 3. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013. PMID: 23681309 Free article.
Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to In Vivo Studies.
Notaro A, Frei A, Rubbiani R, Jakubaszek M, Basu U, Koch S, Mari C, Dotou M, Blacque O, Gouyon J, Bedioui F, Rotthowe N, Winter RF, Goud B, Ferrari S, Tharaud M, Řezáčová M, Humajová J, Tomšík P, Gasser G. Notaro A, et al. Among authors: tomsik p. J Med Chem. 2020 May 28;63(10):5568-5584. doi: 10.1021/acs.jmedchem.0c00431. Epub 2020 May 7. J Med Chem. 2020. PMID: 32319768
27 results