Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-κB ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling pathway.
Tomomura M, Hasegawa H, Suda N, Sakagami H, Tomomura A.
Tomomura M, et al. Among authors: tomomura a.
J Biol Chem. 2012 May 25;287(22):17963-74. doi: 10.1074/jbc.M112.358796. Epub 2012 Mar 29.
J Biol Chem. 2012.
PMID: 22461633
Free PMC article.
Recently, we reported that serum calcium-decreasing factor, caldecrin, which is a secretory-type serine protease isolated from the pancreas, inhibits osteoclast differentiation by suppression of NFATc1 activity regardless of its own protease activity (Hasegawa, H., Kido, S., T …
Recently, we reported that serum calcium-decreasing factor, caldecrin, which is a secretory-type serine protease isolated from the pancreas, …