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Extensive weight loss reduces glycan age by altering IgG N-glycosylation.
Greto VL, Cvetko A, Štambuk T, Dempster NJ, Kifer D, Deriš H, Cindrić A, Vučković F, Falchi M, Gillies RS, Tomlinson JW, Gornik O, Sgromo B, Spector TD, Menni C, Geremia A, Arancibia-Cárcamo CV, Lauc G. Greto VL, et al. Among authors: tomlinson jw. Int J Obes (Lond). 2021 Jul;45(7):1521-1531. doi: 10.1038/s41366-021-00816-3. Epub 2021 May 3. Int J Obes (Lond). 2021. PMID: 33941843 Free PMC article.
PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.
Guida C, Stephen SD, Watson M, Dempster N, Larraufie P, Marjot T, Cargill T, Rickers L, Pavlides M, Tomlinson J, Cobbold JFL, Zhao CM, Chen D, Gribble F, Reimann F, Gillies R, Sgromo B, Rorsman P, Ryan JD, Ramracheya RD. Guida C, et al. EBioMedicine. 2019 Feb;40:67-76. doi: 10.1016/j.ebiom.2018.12.040. Epub 2019 Jan 11. EBioMedicine. 2019. PMID: 30639417 Free PMC article.
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.
Nikolaou N, Gathercole LL, Marchand L, Althari S, Dempster NJ, Green CJ, van de Bunt M, McNeil C, Arvaniti A, Hughes BA, Sgromo B, Gillies RS, Marschall HU, Penning TM, Ryan J, Arlt W, Hodson L, Tomlinson JW. Nikolaou N, et al. Among authors: tomlinson jw. Metabolism. 2019 Oct;99:67-80. doi: 10.1016/j.metabol.2019.153947. Epub 2019 Jul 19. Metabolism. 2019. PMID: 31330134 Free PMC article.
Differential activity and expression of human 5β-reductase (AKR1D1) splice variants.
Appanna N, Gibson H, Gangitano E, Dempster NJ, Morris K, George S, Arvaniti A, Gathercole LL, Keevil B, Penning TM, Storbeck KH, Tomlinson JW, Nikolaou N. Appanna N, et al. Among authors: tomlinson jw. J Mol Endocrinol. 2021 Mar;66(3):181-194. doi: 10.1530/JME-20-0160. J Mol Endocrinol. 2021. PMID: 33502336 Free PMC article.
AKR1D1 knockout mice develop a sex-dependent metabolic phenotype.
Gathercole LL, Nikolaou N, Harris SE, Arvaniti A, Poolman TM, Hazlehurst JM, Kratschmar DV, Todorčević M, Moolla A, Dempster N, Pink RC, Saikali MF, Bentley L, Penning TM, Ohlsson C, Cummins CL, Poutanen M, Odermatt A, Cox RD, Tomlinson JW. Gathercole LL, et al. Among authors: tomlinson jw. J Endocrinol. 2022 Apr 13;253(3):97-113. doi: 10.1530/JOE-21-0280. J Endocrinol. 2022. PMID: 35318963 Free PMC article.
Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT).
Woods CP, Corrigan M, Gathercole L, Taylor A, Hughes B, Gaoatswe G, Manolopoulos K, Hogan AE, O'Connell J, Stewart PM, Tomlinson JW, O'Shea D, Sherlock M. Woods CP, et al. Among authors: tomlinson jw. J Clin Endocrinol Metab. 2015 Apr;100(4):1434-44. doi: 10.1210/jc.2014-4120. Epub 2015 Jan 20. J Clin Endocrinol Metab. 2015. PMID: 25603461 Clinical Trial.
205 results