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Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man.
Hazlehurst JM, Oprescu AI, Nikolaou N, Di Guida R, Grinbergs AE, Davies NP, Flintham RB, Armstrong MJ, Taylor AE, Hughes BA, Yu J, Hodson L, Dunn WB, Tomlinson JW. Hazlehurst JM, et al. Among authors: tomlinson jw. J Clin Endocrinol Metab. 2016 Jan;101(1):103-13. doi: 10.1210/jc.2015-2928. Epub 2015 Nov 17. J Clin Endocrinol Metab. 2016. PMID: 26574953 Free PMC article. Clinical Trial.
AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.
Nikolaou N, Gathercole LL, Kirkwood L, Dunford JE, Hughes BA, Gilligan LC, Oppermann U, Penning TM, Arlt W, Hodson L, Tomlinson JW. Nikolaou N, et al. Among authors: tomlinson jw. J Steroid Biochem Mol Biol. 2019 May;189:218-227. doi: 10.1016/j.jsbmb.2019.02.002. Epub 2019 Feb 12. J Steroid Biochem Mol Biol. 2019. PMID: 30769091 Free PMC article.
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.
Nikolaou N, Gathercole LL, Marchand L, Althari S, Dempster NJ, Green CJ, van de Bunt M, McNeil C, Arvaniti A, Hughes BA, Sgromo B, Gillies RS, Marschall HU, Penning TM, Ryan J, Arlt W, Hodson L, Tomlinson JW. Nikolaou N, et al. Among authors: tomlinson jw. Metabolism. 2019 Oct;99:67-80. doi: 10.1016/j.metabol.2019.153947. Epub 2019 Jul 19. Metabolism. 2019. PMID: 31330134 Free PMC article.
Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo.
Nikolaou N, Arvaniti A, Appanna N, Sharp A, Hughes BA, Digweed D, Whitaker MJ, Ross R, Arlt W, Penning TM, Morris K, George S, Keevil BG, Hodson L, Gathercole LL, Tomlinson JW. Nikolaou N, et al. Among authors: tomlinson jw. J Endocrinol. 2020 May;245(2):207-218. doi: 10.1530/JOE-19-0473. J Endocrinol. 2020. PMID: 32106090 Free PMC article.
Sodium-glucose cotransporter 2 inhibition does not reduce hepatic steatosis in overweight, insulin-resistant patients without type 2 diabetes.
Marjot T, Green CJ, Charlton CA, Cornfield T, Hazlehurst J, Moolla A, White S, Francis J, Neubauer S, Cobbold JF, Hodson L, Tomlinson JW. Marjot T, et al. Among authors: tomlinson jw. JGH Open. 2019 Nov 5;4(3):433-440. doi: 10.1002/jgh3.12274. eCollection 2020 Jun. JGH Open. 2019. PMID: 32514450 Free PMC article.
Co-administration of 5α-reductase Inhibitors Worsens the Adverse Metabolic Effects of Prescribed Glucocorticoids.
Othonos N, Marjot T, Woods C, Hazlehurst JM, Nikolaou N, Pofi R, White S, Bonaventura I, Webster C, Duffy J, Cornfield T, Moolla A, Isidori AM, Hodson L, Tomlinson JW. Othonos N, et al. Among authors: tomlinson jw. J Clin Endocrinol Metab. 2020 Sep 1;105(9):e3316-28. doi: 10.1210/clinem/dgaa408. J Clin Endocrinol Metab. 2020. PMID: 32594135 Free PMC article. Clinical Trial.
206 results