Tomlinson I - Search Results

1

The mini-driver model of polygenic cancer evolution.

Castro-Giner F, Ratcliffe P, Tomlinson I. Castro-Giner F, et al. Among authors: tomlinson i. Nat Rev Cancer. 2015 Nov;15(11):680-5. doi: 10.1038/nrc3999. Epub 2015 Oct 12. Nat Rev Cancer. 2015. PMID: 26456849 Review.

2

Mutations in normal breast tissue and breast tumours.

Tomlinson IP. Tomlinson IP. Breast Cancer Res. 2001;3(5):299-303. doi: 10.1186/bcr311. Epub 2001 Jul 26. Breast Cancer Res. 2001. PMID: 11597318 Free PMC article. Review.

3

Genomic instability--the engine of tumorigenesis?

Sieber OM, Heinimann K, Tomlinson IP. Sieber OM, et al. Nat Rev Cancer. 2003 Sep;3(9):701-8. doi: 10.1038/nrc1170. Nat Rev Cancer. 2003. PMID: 12951589 Review.

4

Tissue, cell and stage specificity of (epi)mutations in cancers.

Sieber OM, Tomlinson SR, Tomlinson IP. Sieber OM, et al. Nat Rev Cancer. 2005 Aug;5(8):649-55. doi: 10.1038/nrc1674. Nat Rev Cancer. 2005. PMID: 16056260 Review.

5

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability.

Kemp Z, Rowan A, Chambers W, Wortham N, Halford S, Sieber O, Mortensen N, von Herbay A, Gunther T, Ilyas M, Tomlinson I. Kemp Z, et al. Among authors: tomlinson i. Cancer Res. 2005 Dec 15;65(24):11361-6. doi: 10.1158/0008-5472.CAN-05-2565. Cancer Res. 2005. PMID: 16357143

6

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.

Bardella C, El-Bahrawy M, Frizzell N, Adam J, Ternette N, Hatipoglu E, Howarth K, O'Flaherty L, Roberts I, Turner G, Taylor J, Giaslakiotis K, Macaulay VM, Harris AL, Chandra A, Lehtonen HJ, Launonen V, Aaltonen LA, Pugh CW, Mihai R, Trudgian D, Kessler B, Baynes JW, Ratcliffe PJ, Tomlinson IP, Pollard PJ. Bardella C, et al. Among authors: tomlinson ip. J Pathol. 2011 Sep;225(1):4-11. doi: 10.1002/path.2932. Epub 2011 Jun 1. J Pathol. 2011. PMID: 21630274

7

SDH mutations in cancer.

Bardella C, Pollard PJ, Tomlinson I. Bardella C, et al. Among authors: tomlinson i. Biochim Biophys Acta. 2011 Nov;1807(11):1432-43. doi: 10.1016/j.bbabio.2011.07.003. Epub 2011 Jul 13. Biochim Biophys Acta. 2011. PMID: 21771581 Free article. Review.

8

CDC4/FBXW7 and the 'just enough' model of tumourigenesis.

Davis H, Tomlinson I. Davis H, et al. Among authors: tomlinson i. J Pathol. 2012 Jun;227(2):131-5. doi: 10.1002/path.4004. Epub 2012 Apr 18. J Pathol. 2012. PMID: 22323043 Free PMC article.

9

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

Schödel J, Bardella C, Sciesielski LK, Brown JM, Pugh CW, Buckle V, Tomlinson IP, Ratcliffe PJ, Mole DR. Schödel J, et al. Nat Genet. 2012 Mar 11;44(4):420-5, S1-2. doi: 10.1038/ng.2204. Nat Genet. 2012. PMID: 22406644 Free PMC article.

10

The continuum model of selection in human tumors: general paradigm or niche product?

Leedham S, Tomlinson I. Leedham S, et al. Among authors: tomlinson i. Cancer Res. 2012 Jul 1;72(13):3131-4. doi: 10.1158/0008-5472.CAN-12-1052. Epub 2012 May 2. Cancer Res. 2012. PMID: 22552286 Free article.

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