Tomkinson NP - Search Results

1

Components of successful lead generation.

Davis AM, Keeling DJ, Steele J, Tomkinson NP, Tinker AC. Davis AM, et al. Among authors: tomkinson np. Curr Top Med Chem. 2005;5(4):421-39. doi: 10.2174/1568026053828411. Curr Top Med Chem. 2005. PMID: 15892684 Review.

2

QSAR modeling using automatically updating correction libraries: application to a human plasma protein binding model.

Rodgers SL, Davis AM, Tomkinson NP, van de Waterbeemd H. Rodgers SL, et al. Among authors: tomkinson np. J Chem Inf Model. 2007 Nov-Dec;47(6):2401-7. doi: 10.1021/ci700197x. Epub 2007 Sep 22. J Chem Inf Model. 2007. PMID: 17887744

3

Predictivity of Simulated ADME AutoQSAR Models over Time.

Rodgers SL, Davis AM, Tomkinson NP, van de Waterbeemd H. Rodgers SL, et al. Among authors: tomkinson np. Mol Inform. 2011 Mar 14;30(2-3):256-66. doi: 10.1002/minf.201000160. Epub 2011 Mar 17. Mol Inform. 2011. PMID: 27466779

4

P2T purinoceptor antagonists. A QSAR study of some 2-substituted ATP analogues.

Tomkinson NP, Marriott DP, Cage PA, Cox D, Davis AM, Flower DR, Gensmantel NP, Humphries RG, Ingall AH, Kindon ND. Tomkinson NP, et al. J Pharm Pharmacol. 1996 Feb;48(2):206-9. doi: 10.1111/j.2042-7158.1996.tb07124.x. J Pharm Pharmacol. 1996. PMID: 8935173

5

Effect of lipophilicity modulation on inhibition of human rhinovirus capsid binders.

Morley A, Tomkinson N, Cook A, MacDonald C, Weaver R, King S, Jenkinson L, Unitt J, McCrae C, Phillips T. Morley A, et al. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6031-5. doi: 10.1016/j.bmcl.2011.08.083. Epub 2011 Aug 24. Bioorg Med Chem Lett. 2011. PMID: 21907579

6

A rapid computational filter for predicting the rate of human renal clearance.

Paine SW, Barton P, Bird J, Denton R, Menochet K, Smith A, Tomkinson NP, Chohan KK. Paine SW, et al. Among authors: tomkinson np. J Mol Graph Model. 2010 Dec;29(4):529-37. doi: 10.1016/j.jmgm.2010.10.003. Epub 2010 Oct 20. J Mol Graph Model. 2010. PMID: 21075652

7

Selection of a screening panel of rhinoviral serotypes.

Tomkinson N, Wenlock M, McCrae C. Tomkinson N, et al. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7494-8. doi: 10.1016/j.bmcl.2012.10.037. Epub 2012 Oct 17. Bioorg Med Chem Lett. 2012. PMID: 23122823

8

Identification of a putative intracellular allosteric antagonist binding-site in the CXC chemokine receptors 1 and 2.

Nicholls DJ, Tomkinson NP, Wiley KE, Brammall A, Bowers L, Grahames C, Gaw A, Meghani P, Shelton P, Wright TJ, Mallinder PR. Nicholls DJ, et al. Among authors: tomkinson np. Mol Pharmacol. 2008 Nov;74(5):1193-202. doi: 10.1124/mol.107.044610. Epub 2008 Aug 1. Mol Pharmacol. 2008. PMID: 18676678

9

Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.

Kirton SB, Kemp CA, Tomkinson NP, St-Gallay S, Sutcliffe MJ. Kirton SB, et al. Among authors: tomkinson np. Proteins. 2002 Nov 1;49(2):216-31. doi: 10.1002/prot.10192. Proteins. 2002. PMID: 12211002

10

Designing novel building blocks is an overlooked strategy to improve compound quality.

Goldberg FW, Kettle JG, Kogej T, Perry MW, Tomkinson NP. Goldberg FW, et al. Among authors: tomkinson np. Drug Discov Today. 2015 Jan;20(1):11-7. doi: 10.1016/j.drudis.2014.09.023. Epub 2014 Oct 2. Drug Discov Today. 2015. PMID: 25281855 Review.

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