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Bioequivalence and Relative Bioavailability Studies to Assess a New Acalabrutinib Formulation That Enables Coadministration With Proton-Pump Inhibitors.
Sharma S, Pepin X, Burri H, Zheng L, Kuptsova-Clarkson N, de Jong A, Yu T, MacArthur HL, Majewski M, Byrd JC, Furman RR, Ware JA, Mann J, Ramies D, Munugalavadla V, Sheridan L, Tomkinson H. Sharma S, et al. Among authors: tomkinson h. Clin Pharmacol Drug Dev. 2022 Nov;11(11):1294-1307. doi: 10.1002/cpdd.1153. Epub 2022 Aug 27. Clin Pharmacol Drug Dev. 2022. PMID: 36029150 Free PMC article.
Improved characterization of the pharmacokinetics of acalabrutinib and its pharmacologically active metabolite, ACP-5862, in patients with B-cell malignancies and in healthy subjects using a population pharmacokinetic approach.
Edlund H, Bellanti F, Liu H, Vishwanathan K, Tomkinson H, Ware J, Sharma S, Buil-Bruna N. Edlund H, et al. Among authors: tomkinson h. Br J Clin Pharmacol. 2022 Feb;88(2):846-852. doi: 10.1111/bcp.14988. Epub 2021 Aug 21. Br J Clin Pharmacol. 2022. PMID: 34265100 Free PMC article.
Bioavailability of acalabrutinib suspension delivered via nasogastric tube in the presence or absence of a proton pump inhibitor in healthy subjects.
Sharma S, Pepin X, Cheung J, Zheng L, Wei H, Townsley D, Han D, Majewski M, Ware JA, Mann J, Munugalavadla V, Sheridan L, Patel P, Gupta A, Tomkinson H. Sharma S, et al. Among authors: tomkinson h. Br J Clin Pharmacol. 2022 Oct;88(10):4573-4584. doi: 10.1111/bcp.15362. Epub 2022 May 25. Br J Clin Pharmacol. 2022. PMID: 35466438 Free article. Clinical Trial.
35 results