Tomita T - Search Results

1

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.

Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Young Chang M, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T. Miyagawa T, et al. Among authors: tomita t. Hum Mol Genet. 2016 Jul 15;25(14):2948-2958. doi: 10.1093/hmg/ddw146. Epub 2016 May 14. Hum Mol Genet. 2016. PMID: 27179792

2

Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.

Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T. Morohashi Y, et al. Among authors: tomita t. J Biol Chem. 2002 Apr 26;277(17):14965-75. doi: 10.1074/jbc.M200897200. Epub 2002 Feb 14. J Biol Chem. 2002. PMID: 11847232 Free article.

3

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

Tomita T, Katayama R, Takikawa R, Iwatsubo T. Tomita T, et al. FEBS Lett. 2002 Jun 5;520(1-3):117-21. doi: 10.1016/s0014-5793(02)02802-8. FEBS Lett. 2002. PMID: 12044882 Free article.

4

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Okochi M, et al. Among authors: tomita t. EMBO J. 2002 Oct 15;21(20):5408-16. doi: 10.1093/emboj/cdf541. EMBO J. 2002. PMID: 12374741 Free PMC article.

5

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals.

Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T. Takasugi N, et al. Among authors: tomita t. J Biol Chem. 2002 Dec 20;277(51):50198-205. doi: 10.1074/jbc.M205352200. Epub 2002 Oct 17. J Biol Chem. 2002. PMID: 12388554 Free article.

6

A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface.

Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. Leem JY, et al. Among authors: tomita t. Neurobiol Dis. 2002 Oct;11(1):64-82. doi: 10.1006/nbdi.2002.0546. Neurobiol Dis. 2002. PMID: 12460547

7

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H. Murakami D, et al. Among authors: tomita t. Oncogene. 2003 Mar 13;22(10):1511-6. doi: 10.1038/sj.onc.1206298. Oncogene. 2003. PMID: 12629514

8

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation.

Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T. Takahashi Y, et al. Among authors: tomita t. J Biol Chem. 2003 May 16;278(20):18664-70. doi: 10.1074/jbc.M301619200. Epub 2003 Mar 10. J Biol Chem. 2003. PMID: 12637581 Free article.

9

The role of presenilin cofactors in the gamma-secretase complex.

Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. Takasugi N, et al. Among authors: tomita t. Nature. 2003 Mar 27;422(6930):438-41. doi: 10.1038/nature01506. Epub 2003 Mar 16. Nature. 2003. PMID: 12660785

10

APP processing and synaptic function.

Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. Kamenetz F, et al. Among authors: tomita t. Neuron. 2003 Mar 27;37(6):925-37. doi: 10.1016/s0896-6273(03)00124-7. Neuron. 2003. PMID: 12670422 Free article.

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