Tomáš Smutný - Search Results

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Results by year

Year	Number of Results
2013	3
2014	4
2015	1
2016	6
2017	2
2018	3
2019	5
2020	5
2021	2
2022	2
2023	1
2024	1

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Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model.

Durinova A, Smutna L, Barta P, Kamaraj R, Smutny T, Schmierer B, Pavek P, Trejtnar F. Durinova A, et al. Among authors: smutny t. EJNMMI Radiopharm Chem. 2024 Apr 18;9(1):32. doi: 10.1186/s41181-024-00262-2. EJNMMI Radiopharm Chem. 2024. PMID: 38637347 Free PMC article.

Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.

Mejdrová I, Dušek J, Škach K, Stefela A, Skoda J, Chalupský K, Dohnalová K, Pavkova I, Kronenberger T, Rashidian A, Smutná L, Duchoslav V, Smutny T, Pávek P, Nencka R. Mejdrová I, et al. Among authors: smutny t. J Med Chem. 2023 Feb 23;66(4):2422-2456. doi: 10.1021/acs.jmedchem.2c01140. Epub 2023 Feb 9. J Med Chem. 2023. PMID: 36756805 Free PMC article.

Gene Expression Profiling of 1α,25(OH)₂ D₃ Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes.

Pavek P, Dusek J, Smutny T, Lochman L, Kucera R, Skoda J, Smutna L, Kamaraj R, Soucek P, Vrzal R, Dvorak Z. Pavek P, et al. Among authors: smutny t. Mol Nutr Food Res. 2022 May;66(9):e2200070. doi: 10.1002/mnfr.202200070. Epub 2022 Mar 1. Mol Nutr Food Res. 2022. PMID: 35184385

Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids.

Smutny T, Bernhauerova V, Smutna L, Tebbens JD, Pavek P. Smutny T, et al. Arch Toxicol. 2022 Jan;96(1):195-210. doi: 10.1007/s00204-021-03177-y. Epub 2021 Oct 23. Arch Toxicol. 2022. PMID: 34689256

Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain.

Skoda J, Dusek J, Drastik M, Stefela A, Dohnalova K, Chalupsky K, Smutny T, Micuda S, Gerbal-Chaloin S, Pavek P. Skoda J, et al. Among authors: smutny t. Cells. 2020 Nov 24;9(12):2532. doi: 10.3390/cells9122532. Cells. 2020. PMID: 33255185 Free PMC article.

Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism.

Smutny T, Hyrsova L, Braeuning A, Ingelman-Sundberg M, Pavek P. Smutny T, et al. Arch Toxicol. 2021 Jan;95(1):11-25. doi: 10.1007/s00204-020-02916-x. Epub 2020 Nov 9. Arch Toxicol. 2021. PMID: 33164107 Review.

3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism.

Stefela A, Kaspar M, Drastik M, Holas O, Hroch M, Smutny T, Skoda J, Hutníková M, Pandey AV, Micuda S, Kudova E, Pavek P. Stefela A, et al. Among authors: smutny t. J Steroid Biochem Mol Biol. 2020 Sep;202:105702. doi: 10.1016/j.jsbmb.2020.105702. Epub 2020 Jun 4. J Steroid Biochem Mol Biol. 2020. PMID: 32505574

Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes.

Hendriks DFG, Vorrink SU, Smutny T, Sim SC, Nordling Å, Ullah S, Kumondai M, Jones BC, Johansson I, Andersson TB, Lauschke VM, Ingelman-Sundberg M. Hendriks DFG, et al. Among authors: smutny t. Clin Pharmacol Ther. 2020 Oct;108(4):844-855. doi: 10.1002/cpt.1860. Epub 2020 May 22. Clin Pharmacol Ther. 2020. PMID: 32320483

The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids.

Smutny T, Dusek J, Hyrsova L, Nekvindova J, Horvatova A, Micuda S, Gerbal-Chaloin S, Pavek P. Smutny T, et al. Acta Pharm Sin B. 2020 Jan;10(1):136-152. doi: 10.1016/j.apsb.2019.09.010. Epub 2019 Oct 21. Acta Pharm Sin B. 2020. PMID: 31998607 Free PMC article.

Sesquiterpenes Are Agonists of the Pregnane X Receptor but Do Not Induce the Expression of Phase I Drug-Metabolizing Enzymes in the Human Liver.

Šadibolová M, Zárybnický T, Smutný T, Pávek P, Šubrt Z, Matoušková P, Skálová L, Boušová I. Šadibolová M, et al. Among authors: smutny t. Int J Mol Sci. 2019 Sep 14;20(18):4562. doi: 10.3390/ijms20184562. Int J Mol Sci. 2019. PMID: 31540101 Free PMC article.

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