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Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.
Saitoh T, Amezawa M, Horiuchi J, Nagumo Y, Yamamoto N, Kutsumura N, Ohshita R, Tokuda A, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Hasegawa E, Sakurai T, Uchida Y, Sato T, Gouda H, Tanimura R, Yanagisawa M, Nagase H. Saitoh T, et al. Among authors: tokuda a. Eur J Med Chem. 2022 Oct 5;240:114505. doi: 10.1016/j.ejmech.2022.114505. Epub 2022 Jun 13. Eur J Med Chem. 2022. PMID: 35839689
OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy.
Yamamoto H, Nagumo Y, Ishikawa Y, Irukayama-Tomobe Y, Namekawa Y, Nemoto T, Tanaka H, Takahashi G, Tokuda A, Saitoh T, Nagase H, Funato H, Yanagisawa M. Yamamoto H, et al. Among authors: tokuda a. PLoS One. 2022 Jul 22;17(7):e0271901. doi: 10.1371/journal.pone.0271901. eCollection 2022. PLoS One. 2022. PMID: 35867683 Free PMC article.
Design and Synthesis of Orexin 1 Receptor-Selective Agonists.
Iio K, Hashimoto K, Nagumo Y, Amezawa M, Hasegawa T, Yamamoto N, Kutsumura N, Takeuchi K, Ishikawa Y, Yamamoto H, Tokuda A, Sato T, Uchida Y, Inoue A, Tanimura R, Yanagisawa M, Nagase H, Saitoh T. Iio K, et al. Among authors: tokuda a. J Med Chem. 2023 Apr 27;66(8):5453-5464. doi: 10.1021/acs.jmedchem.2c01773. Epub 2023 Apr 12. J Med Chem. 2023. PMID: 37043436
Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton.
Maeda K, Ohrui S, Tokuda A, Nagumo Y, Yamamoto N, Tanimura R, Saitoh T, Kutsumura N, Nagase H. Maeda K, et al. Among authors: tokuda a. Org Lett. 2023 May 19;25(19):3407-3411. doi: 10.1021/acs.orglett.3c00956. Epub 2023 May 8. Org Lett. 2023. PMID: 37154730
100 results