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Hepatic sinusoidal obstruction syndrome during maintenance therapy of childhood acute lymphoblastic leukemia is associated with continuous asparaginase therapy and mercaptopurine metabolites.
Toksvang LN, De Pietri S, Nielsen SN, Nersting J, Albertsen BK, Wehner PS, Rosthøj S, Lähteenmäki PM, Nilsson D, Nystad TA, Grell K, Frandsen TL, Schmiegelow K. Toksvang LN, et al. Pediatr Blood Cancer. 2017 Sep;64(9). doi: 10.1002/pbc.26519. Epub 2017 Apr 19. Pediatr Blood Cancer. 2017. PMID: 28423235 Clinical Trial.
No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
Nielsen SN, Toksvang LN, Grell K, Nersting J, Abrahamsson J, Lund B, Kanerva J, Jónsson ÓG, Vaitkeviciene G, Pruunsild K, Appell ML, Hjalgrim LL, Schmiegelow K. Nielsen SN, et al. Among authors: toksvang ln. Cancer Chemother Pharmacol. 2021 Aug;88(2):271-279. doi: 10.1007/s00280-021-04281-7. Epub 2021 Apr 29. Cancer Chemother Pharmacol. 2021. PMID: 33928426
Maintenance therapy and risk of osteonecrosis in children and young adults with acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
Toksvang LN, Andrés-Jensen L, Rank CU, Niinimäki R, Nersting J, Nielsen SN, Mogensen SS, Harila-Saari A, Abrahamsson J, Joelsson J, Overgaard UM, Quist-Paulsen P, Griškevičius L, Jónsson ÓG, Vaitkevičienė G, Frandsen TL, Toft N, Grell K, Schmiegelow K. Toksvang LN, et al. Cancer Chemother Pharmacol. 2021 Nov;88(5):911-917. doi: 10.1007/s00280-021-04316-z. Epub 2021 Jun 18. Cancer Chemother Pharmacol. 2021. PMID: 34145469 Clinical Trial.
Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0-45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol.
Toksvang LN, Als-Nielsen B, Bacon C, Bertasiute R, Duarte X, Escherich G, Helgadottir EA, Johannsdottir IR, Jónsson ÓG, Kozlowski P, Langenskjöld C, Lepik K, Niinimäki R, Overgaard UM, Punab M, Räty R, Segers H, van der Sluis I, Smith OP, Strullu M, Vaitkevičienė G, Wik HS, Heyman M, Schmiegelow K. Toksvang LN, et al. BMC Cancer. 2022 May 2;22(1):483. doi: 10.1186/s12885-022-09522-3. BMC Cancer. 2022. PMID: 35501736 Free PMC article.
DNA-thioguanine concentration and relapse risk in children and young adults with acute lymphoblastic leukemia: an IPD meta-analysis.
Toksvang LN, Grell K, Nersting J, Degn M, Nielsen SN, Abrahamsson J, Lund B, Kanerva J, Jónsson ÓG, Lepik K, Vaitkevičienė G, Griškevičius L, Quist-Paulsen P, Vora A, Moorman AV, Murdy D, Zimmermann M, Möricke A, Bostrom B, Joshi J, Hjalgrim LL, Dalhoff KP, Als-Nielsen B, Schmiegelow K. Toksvang LN, et al. Leukemia. 2022 Jan;36(1):33-41. doi: 10.1038/s41375-021-01182-9. Epub 2021 Jun 26. Leukemia. 2022. PMID: 34175901
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