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Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma.
Allam VSRR, Pavlidis S, Liu G, Kermani NZ, Simpson J, To J, Donnelly S, Guo YK, Hansbro PM, Phipps S, Morand EF, Djukanovic R, Sterk P, Chung KF, Adcock I, Harris J, Sukkar MB. Allam VSRR, et al. Among authors: to j. Thorax. 2023 Jul;78(7):661-673. doi: 10.1136/thorax-2021-218555. Epub 2022 Nov 7. Thorax. 2023. PMID: 36344253
The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma.
Tanaka A, Allam VSRR, Simpson J, Tiberti N, Shiels J, To J, Lund M, Combes V, Weldon S, Taggart C, Dalton JP, Phipps S, Sukkar MB, Donnelly S. Tanaka A, et al. Among authors: to j. J Allergy Clin Immunol. 2018 Jun;141(6):2316-2319. doi: 10.1016/j.jaci.2018.01.050. Epub 2018 Mar 6. J Allergy Clin Immunol. 2018. PMID: 29522851 No abstract available.
The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages.
Alvarado R, To J, Lund ME, Pinar A, Mansell A, Robinson MW, O'Brien BA, Dalton JP, Donnelly S. Alvarado R, et al. Among authors: to j. FASEB J. 2017 Jan;31(1):85-95. doi: 10.1096/fj.201500093R. Epub 2016 Sep 28. FASEB J. 2017. PMID: 27682204
Helminth parasites secrete molecules that interact with innate immune cells, modulating their activity to ultimately determine the phenotype of differentiated T cells, thus creating an immune environment that is conducive to sustaining chronic infection. ...We propo …
Helminth parasites secrete molecules that interact with innate immune cells, modulating their activity to ultimately determine the ph …
206 results