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Drug-Initiated Activity Metabolomics Identifies Myristoylglycine as a Potent Endogenous Metabolite for Human Brown Fat Differentiation.
Guijas C, To A, Montenegro-Burke JR, Domingo-Almenara X, Alipio-Gloria Z, Kok BP, Saez E, Alvarez NH, Johnson KA, Siuzdak G. Guijas C, et al. Among authors: to a. Metabolites. 2022 Aug 16;12(8):749. doi: 10.3390/metabo12080749. Metabolites. 2022. PMID: 36005620 Free PMC article.
The screening allowed us to discover that zafirlukast, an FDA-approved small molecule drug commonly used to treat asthma, was able to differentiate adipocyte precursors and white-biased adipocytes into functional brown adipocytes. However, zafirlukast is toxi …
The screening allowed us to discover that zafirlukast, an FDA-approved small molecule drug commonly used to treat asthma, was …
A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction.
Zhong L, Tran T, Baguley TD, Lee SJ, Henke A, To A, Li S, Yu S, Grieco FA, Roland J, Schultz PG, Eizirik DL, Rogers N, Chartterjee AK, Tremblay MS, Shen W. Zhong L, et al. Among authors: to a. Br J Pharmacol. 2018 Sep;175(17):3470-3485. doi: 10.1111/bph.14388. Epub 2018 Jul 14. Br J Pharmacol. 2018. PMID: 29888783 Free PMC article.
EXPERIMENTAL APPROACH: Diabetogenic media, composed of IL-1beta, IFN-gamma and high glucose, were used to induce mitochondrial stress in rat insulin-producing INS1E cells, and a high-content image-based screen of small molecule modulators of Casp9 pathway was perfor …
EXPERIMENTAL APPROACH: Diabetogenic media, composed of IL-1beta, IFN-gamma and high glucose, were used to induce mitochondrial stress …
Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy.
Bhandari D, Lopez-Sanchez I, To A, Lo IC, Aznar N, Leyme A, Gupta V, Niesman I, Maddox AL, Garcia-Marcos M, Farquhar MG, Ghosh P. Bhandari D, et al. Among authors: to a. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4874-83. doi: 10.1073/pnas.1514157112. Epub 2015 Aug 18. Proc Natl Acad Sci U S A. 2015. PMID: 26286990 Free PMC article.
Here we reveal the molecular mechanism by which phosphorylation of GIV by cyclin-dependent kinase 5 (CDK5) triggers GIV's ability to bind and activate Galphai in response to growth factors and modulate downstream signals to establish a dichotomy betwee …
Here we reveal the molecular mechanism by which phosphorylation of GIV by cyclin-dependent kinase 5 (CDK5) triggers GIV's ability to …
Tonal interference in word learning? A comparison of Cantonese and French.
Piot L, Chen H, Picaud A, Dos Santos M, Granjon L, Luo Z, To AWH, Lai RY, Cheung H, Nazzi T. Piot L, et al. Among authors: to awh. J Exp Child Psychol. 2024 Jun;242:105883. doi: 10.1016/j.jecp.2024.105883. Epub 2024 Feb 26. J Exp Child Psychol. 2024. PMID: 38412568 Free article.
201 results