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Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.
Arlia-Ciommo A, Leonov A, Mohammad K, Beach A, Richard VR, Bourque SD, Burstein MT, Goldberg AA, Kyryakov P, Gomez-Perez A, Koupaki O, Titorenko VI. Arlia-Ciommo A, et al. Among authors: titorenko vi. Oncotarget. 2018 Oct 9;9(79):34945-34971. doi: 10.18632/oncotarget.26188. eCollection 2018 Oct 9. Oncotarget. 2018. PMID: 30405886 Free PMC article.
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.
Goldberg AA, Richard VR, Kyryakov P, Bourque SD, Beach A, Burstein MT, Glebov A, Koupaki O, Boukh-Viner T, Gregg C, Juneau M, English AM, Thomas DY, Titorenko VI. Goldberg AA, et al. Among authors: titorenko vi. Aging (Albany NY). 2010 Jul;2(7):393-414. doi: 10.18632/aging.100168. Aging (Albany NY). 2010. PMID: 20622262 Free PMC article.
Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.
Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI. Beach A, et al. Among authors: titorenko vi. Cell Cycle. 2015;14(11):1643-56. doi: 10.1080/15384101.2015.1026493. Cell Cycle. 2015. PMID: 25839782 Free PMC article.
Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast.
Leonov A, Arlia-Ciommo A, Bourque SD, Koupaki O, Kyryakov P, Dakik P, McAuley M, Medkour Y, Mohammad K, Di Maulo T, Titorenko VI. Leonov A, et al. Among authors: titorenko vi. Oncotarget. 2017 May 9;8(19):30672-30691. doi: 10.18632/oncotarget.16766. Oncotarget. 2017. PMID: 28410198 Free PMC article.
Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state.
Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, Roofigari-Esfahani N, Rosanelli L, Titorenko VI. Leonov A, et al. Among authors: titorenko vi. Oncotarget. 2017 Sep 1;8(41):69328-69350. doi: 10.18632/oncotarget.20614. eCollection 2017 Sep 19. Oncotarget. 2017. PMID: 29050207 Free PMC article.
115 results