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In search of housekeeping pathways that regulate longevity.
Beach A, Titorenko VI. Beach A, et al. Among authors: titorenko vi. Cell Cycle. 2011 Sep 15;10(18):3042-4. doi: 10.4161/cc.10.18.16947. Epub 2011 Sep 15. Cell Cycle. 2011. PMID: 21862878 No abstract available.
Macromitophagy, neutral lipids synthesis, and peroxisomal fatty acid oxidation protect yeast from "liponecrosis", a previously unknown form of programmed cell death.
Sheibani S, Richard VR, Beach A, Leonov A, Feldman R, Mattie S, Khelghatybana L, Piano A, Greenwood M, Vali H, Titorenko VI. Sheibani S, et al. Among authors: titorenko vi. Cell Cycle. 2014;13(1):138-47. doi: 10.4161/cc.26885. Epub 2013 Oct 28. Cell Cycle. 2014. PMID: 24196447 Free PMC article.
Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.
Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI. Beach A, et al. Among authors: titorenko vi. Cell Cycle. 2015;14(11):1643-56. doi: 10.1080/15384101.2015.1026493. Cell Cycle. 2015. PMID: 25839782 Free PMC article.
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.
Goldberg AA, Richard VR, Kyryakov P, Bourque SD, Beach A, Burstein MT, Glebov A, Koupaki O, Boukh-Viner T, Gregg C, Juneau M, English AM, Thomas DY, Titorenko VI. Goldberg AA, et al. Among authors: titorenko vi. Aging (Albany NY). 2010 Jul;2(7):393-414. doi: 10.18632/aging.100168. Aging (Albany NY). 2010. PMID: 20622262 Free PMC article.
Mitochondrial membrane lipidome defines yeast longevity.
Beach A, Richard VR, Leonov A, Burstein MT, Bourque SD, Koupaki O, Juneau M, Feldman R, Iouk T, Titorenko VI. Beach A, et al. Among authors: titorenko vi. Aging (Albany NY). 2013 Jul;5(7):551-74. doi: 10.18632/aging.100578. Aging (Albany NY). 2013. PMID: 23924582 Free PMC article.
Mechanism of liponecrosis, a distinct mode of programmed cell death.
Richard VR, Beach A, Piano A, Leonov A, Feldman R, Burstein MT, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Baptista S, Campbell C, Goncharov D, Pannu S, Patrinos D, Sadri B, Svistkova V, Victor A, Titorenko VI. Richard VR, et al. Among authors: titorenko vi. Cell Cycle. 2014;13(23):3707-26. doi: 10.4161/15384101.2014.965003. Cell Cycle. 2014. PMID: 25483081 Free PMC article.
A novel function of lipid droplets in regulating longevity.
Goldberg AA, Bourque SD, Kyryakov P, Boukh-Viner T, Gregg C, Beach A, Burstein MT, Machkalyan G, Richard V, Rampersad S, Titorenko VI. Goldberg AA, et al. Among authors: titorenko vi. Biochem Soc Trans. 2009 Oct;37(Pt 5):1050-5. doi: 10.1042/BST0371050. Biochem Soc Trans. 2009. PMID: 19754450
115 results