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Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate.
Zhao S, Jang C, Liu J, Uehara K, Gilbert M, Izzo L, Zeng X, Trefely S, Fernandez S, Carrer A, Miller KD, Schug ZT, Snyder NW, Gade TP, Titchenell PM, Rabinowitz JD, Wellen KE. Zhao S, et al. Among authors: titchenell pm. Nature. 2020 Mar;579(7800):586-591. doi: 10.1038/s41586-020-2101-7. Epub 2020 Mar 18. Nature. 2020. PMID: 32214246 Free PMC article.
AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology.
Jaiswal N, Gavin M, Loro E, Sostre-Colón J, Roberson PA, Uehara K, Rivera-Fuentes N, Neinast M, Arany Z, Kimball SR, Khurana TS, Titchenell PM. Jaiswal N, et al. Among authors: titchenell pm. J Cachexia Sarcopenia Muscle. 2022 Feb;13(1):495-514. doi: 10.1002/jcsm.12846. Epub 2021 Nov 9. J Cachexia Sarcopenia Muscle. 2022. PMID: 34751006 Free PMC article.
Curing Fatty Liver with Oxysterols?
Uehara K, Titchenell PM. Uehara K, et al. Among authors: titchenell pm. Cell Mol Gastroenterol Hepatol. 2022;13(4):1265-1266. doi: 10.1016/j.jcmgh.2022.01.020. Epub 2022 Feb 12. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35167817 Free PMC article. No abstract available.
Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1.
Gosis BS, Wada S, Thorsheim C, Li K, Jung S, Rhoades JH, Yang Y, Brandimarto J, Li L, Uehara K, Jang C, Lanza M, Sanford NB, Bornstein MR, Jeong S, Titchenell PM, Biddinger SB, Arany Z. Gosis BS, et al. Among authors: titchenell pm. Science. 2022 Apr 15;376(6590):eabf8271. doi: 10.1126/science.abf8271. Epub 2022 Apr 15. Science. 2022. PMID: 35420934 Free PMC article.
37 results