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High mobility group box 1 orchestrates tissue regeneration via CXCR4.
Tirone M, Tran NL, Ceriotti C, Gorzanelli A, Canepari M, Bottinelli R, Raucci A, Di Maggio S, Santiago C, Mellado M, Saclier M, François S, Careccia G, He M, De Marchis F, Conti V, Ben Larbi S, Cuvellier S, Casalgrandi M, Preti A, Chazaud B, Al-Abed Y, Messina G, Sitia G, Brunelli S, Bianchi ME, Vénéreau E. Tirone M, et al. J Exp Med. 2018 Jan 2;215(1):303-318. doi: 10.1084/jem.20160217. Epub 2017 Dec 4. J Exp Med. 2018. PMID: 29203538 Free PMC article.
Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment.
De Leo F, Quilici G, Tirone M, De Marchis F, Mannella V, Zucchelli C, Preti A, Gori A, Casalgrandi M, Mezzapelle R, Bianchi ME, Musco G. De Leo F, et al. Among authors: tirone m. EMBO Rep. 2019 Oct 4;20(10):e47788. doi: 10.15252/embr.201947788. Epub 2019 Aug 14. EMBO Rep. 2019. PMID: 31418171 Free PMC article.
Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy.
Careccia G, Saclier M, Tirone M, Ruggieri E, Principi E, Raffaghello L, Torchio S, Recchia D, Canepari M, Gorzanelli A, Ferrara M, Castellani P, Rubartelli A, Rovere-Querini P, Casalgrandi M, Preti A, Lorenzetti I, Bruno C, Bottinelli R, Brunelli S, Previtali SC, Bianchi ME, Messina G, Vénéreau E. Careccia G, et al. Among authors: tirone m. Sci Transl Med. 2021 Jun 2;13(596):eaay8416. doi: 10.1126/scitranslmed.aay8416. Sci Transl Med. 2021. PMID: 34078746
Macrophages Guard Endothelial Lineage by Hindering Endothelial-to-Mesenchymal Transition: Implications for the Pathogenesis of Systemic Sclerosis.
Nicolosi PA, Tombetti E, Giovenzana A, Donè E, Pulcinelli E, Meneveri R, Tirone M, Maugeri N, Rovere-Querini P, Manfredi AA, Brunelli S. Nicolosi PA, et al. Among authors: tirone m. J Immunol. 2019 Jul 1;203(1):247-258. doi: 10.4049/jimmunol.1800883. Epub 2019 May 24. J Immunol. 2019. PMID: 31127033 Free article.
High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva.
Cappato S, Tonachini L, Giacopelli F, Tirone M, Galietta LJ, Sormani M, Giovenzana A, Spinelli AE, Canciani B, Brunelli S, Ravazzolo R, Bocciardi R. Cappato S, et al. Among authors: tirone m. Dis Model Mech. 2016 Jun 1;9(6):685-96. doi: 10.1242/dmm.023929. Epub 2016 Apr 28. Dis Model Mech. 2016. PMID: 27125279 Free PMC article.
Severe Heterotopic Ossification in the Skeletal Muscle and Endothelial Cells Recruitment to Chondrogenesis Are Enhanced by Monocyte/Macrophage Depletion.
Tirone M, Giovenzana A, Vallone A, Zordan P, Sormani M, Nicolosi PA, Meneveri R, Gigliotti CR, Spinelli AE, Bocciardi R, Ravazzolo R, Cifola I, Brunelli S. Tirone M, et al. Front Immunol. 2019 Jul 19;10:1640. doi: 10.3389/fimmu.2019.01640. eCollection 2019. Front Immunol. 2019. PMID: 31396210 Free PMC article.
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