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Detrimental proarrhythmogenic interaction of Ca2+/calmodulin-dependent protein kinase II and NaV1.8 in heart failure.
Nat Commun. 2021 Nov 15;12(1):6586. doi: 10.1038/s41467-021-26690-1.
Nat Commun. 2021.
PMID: 34782600
Free PMC article.
Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart.
Dybkova N, Ahmad S, Pabel S, Tirilomis P, Hartmann N, Fischer TH, Bengel P, Tirilomis T, Ljubojevic S, Renner A, Gummert J, Ellenberger D, Wagner S, Frey N, Maier LS, Streckfuss-Bömeke K, Hasenfuss G, Sossalla S.
Dybkova N, et al. Among authors: tirilomis p.
Cardiovasc Res. 2018 Nov 1;114(13):1728-1737. doi: 10.1093/cvr/cvy152.
Cardiovasc Res. 2018.
PMID: 29931291
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The functional consequences of sodium channel NaV 1.8 in human left ventricular hypertrophy.
Ahmad S, Tirilomis P, Pabel S, Dybkova N, Hartmann N, Molina CE, Tirilomis T, Kutschka I, Frey N, Maier LS, Hasenfuss G, Streckfuss-Bömeke K, Sossalla S.
Ahmad S, et al. Among authors: tirilomis p.
ESC Heart Fail. 2019 Feb;6(1):154-163. doi: 10.1002/ehf2.12378. Epub 2018 Oct 30.
ESC Heart Fail. 2019.
PMID: 30378291
Free PMC article.
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Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice.
Pabel S, Ahmad S, Tirilomis P, Stehle T, Mustroph J, Knierim M, Dybkova N, Bengel P, Holzamer A, Hilker M, Streckfuss-Bömeke K, Hasenfuss G, Maier LS, Sossalla S.
Pabel S, et al. Among authors: tirilomis p.
Basic Res Cardiol. 2020 Feb 20;115(2):20. doi: 10.1007/s00395-020-0780-8.
Basic Res Cardiol. 2020.
PMID: 32078054
Free PMC article.
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Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia.
Bengel P, Ahmad S, Tirilomis P, Trum M, Dybkova N, Wagner S, Maier LS, Hasenfuß G, Sossalla S.
Bengel P, et al. Among authors: tirilomis p.
J Mol Cell Cardiol. 2020 Jul;144:35-46. doi: 10.1016/j.yjmcc.2020.05.002. Epub 2020 May 11.
J Mol Cell Cardiol. 2020.
PMID: 32418916
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Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression.
Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K.
Mohamed BA, et al. Among authors: tirilomis p.
Sci Transl Med. 2018 Sep 12;10(458):eaan0724. doi: 10.1126/scitranslmed.aan0724.
Sci Transl Med. 2018.
PMID: 30209242
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Empagliflozin directly improves diastolic function in human heart failure.
Pabel S, Wagner S, Bollenberg H, Bengel P, Kovács Á, Schach C, Tirilomis P, Mustroph J, Renner A, Gummert J, Fischer T, Van Linthout S, Tschöpe C, Streckfuss-Bömeke K, Hasenfuss G, Maier LS, Hamdani N, Sossalla S.
Pabel S, et al. Among authors: tirilomis p.
Eur J Heart Fail. 2018 Dec;20(12):1690-1700. doi: 10.1002/ejhf.1328. Epub 2018 Oct 17.
Eur J Heart Fail. 2018.
PMID: 30328645
Free article.
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Sacubitrilat reduces pro-arrhythmogenic sarcoplasmic reticulum Ca2+ leak in human ventricular cardiomyocytes of patients with end-stage heart failure.
Eiringhaus J, Wünsche CM, Tirilomis P, Herting J, Bork N, Nikolaev VO, Hasenfuss G, Sossalla S, Fischer TH.
Eiringhaus J, et al. Among authors: tirilomis p.
ESC Heart Fail. 2020 Oct;7(5):2992-3002. doi: 10.1002/ehf2.12918. Epub 2020 Jul 25.
ESC Heart Fail. 2020.
PMID: 32710603
Free PMC article.
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