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Crystallographic and computational studies on 4-phenyl-N-(beta-D-glucopyranosyl)-1H-1,2,3-triazole-1-acetamide, an inhibitor of glycogen phosphorylase: comparison with alpha-D-glucose, N-acetyl-beta-D-glucopyranosylamine and N-benzoyl-N'-beta-D-glucopyranosyl urea binding.
Alexacou KM, Hayes JM, Tiraidis C, Zographos SE, Leonidas DD, Chrysina ED, Archontis G, Oikonomakos NG, Paul JV, Varghese B, Loganathan D. Alexacou KM, et al. Among authors: tiraidis c. Proteins. 2008 May 15;71(3):1307-23. doi: 10.1002/prot.21837. Proteins. 2008. PMID: 18041758
New inhibitors of glycogen phosphorylase as potential antidiabetic agents.
Somsák L, Czifrák K, Tóth M, Bokor E, Chrysina ED, Alexacou KM, Hayes JM, Tiraidis C, Lazoura E, Leonidas DD, Zographos SE, Oikonomakos NG. Somsák L, et al. Among authors: tiraidis c. Curr Med Chem. 2008;15(28):2933-83. doi: 10.2174/092986708786848659. Curr Med Chem. 2008. PMID: 19075645 Review.
Crystallographic studies on N-azidoacetyl-beta-D-glucopyranosylamine, an inhibitor of glycogen phosphorylase: comparison with N-acetyl-beta-D-glucopyranosylamine.
Petsalakis EI, Chrysina ED, Tiraidis C, Hadjiloi T, Leonidas DD, Oikonomakos NG, Aich U, Varghese B, Loganathan D. Petsalakis EI, et al. Among authors: tiraidis c. Bioorg Med Chem. 2006 Aug 1;14(15):5316-24. doi: 10.1016/j.bmc.2006.03.044. Epub 2006 Apr 17. Bioorg Med Chem. 2006. PMID: 16616506
N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
Nagy V, Felföldi N, Kónya B, Praly JP, Docsa T, Gergely P, Chrysina ED, Tiraidis C, Kosmopoulou MN, Alexacou KM, Konstantakaki M, Leonidas DD, Zographos SE, Oikonomakos NG, Kozmon S, Tvaroška I, Somsák L. Nagy V, et al. Among authors: tiraidis c. Bioorg Med Chem. 2012 Mar 1;20(5):1801-16. doi: 10.1016/j.bmc.2011.12.059. Epub 2012 Jan 20. Bioorg Med Chem. 2012. PMID: 22325154
Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.
Benltifa M, Hayes JM, Vidal S, Gueyrard D, Goekjian PG, Praly JP, Kizilis G, Tiraidis C, Alexacou KM, Chrysina ED, Zographos SE, Leonidas DD, Archontis G, Oikonomakos NG. Benltifa M, et al. Among authors: tiraidis c. Bioorg Med Chem. 2009 Oct 15;17(20):7368-80. doi: 10.1016/j.bmc.2009.08.060. Epub 2009 Sep 2. Bioorg Med Chem. 2009. PMID: 19781947
Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase.
Anagnostou E, Kosmopoulou MN, Chrysina ED, Leonidas DD, Hadjiloi T, Tiraidis C, Zographos SE, Györgydeák Z, Somsák L, Docsa T, Gergely P, Kolisis FN, Oikonomakos NG. Anagnostou E, et al. Among authors: tiraidis c. Bioorg Med Chem. 2006 Jan 1;14(1):181-9. doi: 10.1016/j.bmc.2005.08.010. Epub 2005 Oct 4. Bioorg Med Chem. 2006. PMID: 16213146
11 results