Tinsley HN - Search Results

1

Chronic exposure to a high-fat diet induces hepatic steatosis, impairs nitric oxide bioavailability, and modifies the mitochondrial proteome in mice.

Eccleston HB, Andringa KK, Betancourt AM, King AL, Mantena SK, Swain TM, Tinsley HN, Nolte RN, Nagy TR, Abrams GA, Bailey SM. Eccleston HB, et al. Among authors: tinsley hn. Antioxid Redox Signal. 2011 Jul 15;15(2):447-59. doi: 10.1089/ars.2010.3395. Epub 2011 Mar 31. Antioxid Redox Signal. 2011. PMID: 20919931 Free PMC article.

2

A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.

Piazza GA, Keeton AB, Tinsley HN, Gary BD, Whitt JD, Mathew B, Thaiparambil J, Coward L, Gorman G, Li Y, Sani B, Hobrath JV, Maxuitenko YY, Reynolds RC. Piazza GA, et al. Among authors: tinsley hn. Cancer Prev Res (Phila). 2009 Jun;2(6):572-80. doi: 10.1158/1940-6207.CAPR-09-0001. Epub 2009 May 26. Cancer Prev Res (Phila). 2009. PMID: 19470791 Free PMC article.

3

Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells.

Tinsley HN, Gary BD, Keeton AB, Lu W, Li Y, Piazza GA. Tinsley HN, et al. Cancer Prev Res (Phila). 2011 Aug;4(8):1275-84. doi: 10.1158/1940-6207.CAPR-11-0095. Epub 2011 Apr 19. Cancer Prev Res (Phila). 2011. PMID: 21505183 Free PMC article.

4

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G.

Tinsley HN, Gary BD, Keeton AB, Zhang W, Abadi AH, Reynolds RC, Piazza GA. Tinsley HN, et al. Mol Cancer Ther. 2009 Dec;8(12):3331-40. doi: 10.1158/1535-7163.MCT-09-0758. Mol Cancer Ther. 2009. PMID: 19996273 Free PMC article.

5

Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation.

Lu W, Tinsley HN, Keeton A, Qu Z, Piazza GA, Li Y. Lu W, et al. Among authors: tinsley hn. Eur J Pharmacol. 2009 Jan 5;602(1):8-14. doi: 10.1016/j.ejphar.2008.10.053. Epub 2008 Nov 9. Eur J Pharmacol. 2009. PMID: 19026633 Free PMC article.

6

Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors.

Abadi AH, Ibrahim TM, Abouzid KM, Lehmann J, Tinsley HN, Gary BD, Piazza GA. Abadi AH, et al. Among authors: tinsley hn. Bioorg Med Chem. 2009 Aug 15;17(16):5974-82. doi: 10.1016/j.bmc.2009.06.063. Epub 2009 Jul 3. Bioorg Med Chem. 2009. PMID: 19628397 Free PMC article.

7

Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents.

Abadi AH, Abouel-Ella DA, Ahmed NS, Gary BD, Thaiparambil JT, Tinsley HN, Keeton AB, Piazza GA. Abadi AH, et al. Among authors: tinsley hn. Arzneimittelforschung. 2009;59(8):415-21. doi: 10.1055/s-0031-1296417. Arzneimittelforschung. 2009. PMID: 19813465 Free PMC article.

8

Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach.

Abadi AH, Abouel-Ella DA, Lehmann J, Tinsley HN, Gary BD, Piazza GA, Abdel-Fattah MA. Abadi AH, et al. Among authors: tinsley hn. Eur J Med Chem. 2010 Jan;45(1):90-7. doi: 10.1016/j.ejmech.2009.09.029. Epub 2009 Sep 20. Eur J Med Chem. 2010. PMID: 19836860 Free PMC article.

9

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.

Abadi AH, Gary BD, Tinsley HN, Piazza GA, Abdel-Halim M. Abadi AH, et al. Among authors: tinsley hn. Eur J Med Chem. 2010 Apr;45(4):1278-86. doi: 10.1016/j.ejmech.2009.10.046. Eur J Med Chem. 2010. PMID: 20206015 Free PMC article.

10

Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.

Tinsley HN, Gary BD, Thaiparambil J, Li N, Lu W, Li Y, Maxuitenko YY, Keeton AB, Piazza GA. Tinsley HN, et al. Cancer Prev Res (Phila). 2010 Oct;3(10):1303-13. doi: 10.1158/1940-6207.CAPR-10-0030. Epub 2010 Sep 28. Cancer Prev Res (Phila). 2010. PMID: 20876730 Free PMC article.

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