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A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis.
Andries K, Verhasselt P, Guillemont J, Göhlmann HW, Neefs JM, Winkler H, Van Gestel J, Timmerman P, Zhu M, Lee E, Williams P, de Chaffoy D, Huitric E, Hoffner S, Cambau E, Truffot-Pernot C, Lounis N, Jarlier V. Andries K, et al. Among authors: timmerman p. Science. 2005 Jan 14;307(5707):223-7. doi: 10.1126/science.1106753. Epub 2004 Dec 9. Science. 2005. PMID: 15591164 Clinical Trial.
Selection of a respiratory syncytial virus fusion inhibitor clinical candidate, part 1: improving the pharmacokinetic profile using the structure-property relationship.
Bonfanti JF, Doublet F, Fortin J, Lacrampe J, Guillemont J, Muller P, Queguiner L, Arnoult E, Gevers T, Janssens P, Szel H, Willebrords R, Timmerman P, Wuyts K, Janssens F, Sommen C, Wigerinck P, Andries K. Bonfanti JF, et al. Among authors: timmerman p. J Med Chem. 2007 Sep 20;50(19):4572-84. doi: 10.1021/jm070143x. Epub 2007 Aug 28. J Med Chem. 2007. PMID: 17722899
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.
Guillemont J, Pasquier E, Palandjian P, Vernier D, Gaurrand S, Lewi PJ, Heeres J, de Jonge MR, Koymans LM, Daeyaert FF, Vinkers MH, Arnold E, Das K, Pauwels R, Andries K, de Béthune MP, Bettens E, Hertogs K, Wigerinck P, Timmerman P, Janssen PA. Guillemont J, et al. Among authors: timmerman p. J Med Chem. 2005 Mar 24;48(6):2072-9. doi: 10.1021/jm040838n. J Med Chem. 2005. PMID: 15771449
Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholinopropylaminobenzimidazole derivative (TMC353121).
Bonfanti JF, Meyer C, Doublet F, Fortin J, Muller P, Queguiner L, Gevers T, Janssens P, Szel H, Willebrords R, Timmerman P, Wuyts K, van Remoortere P, Janssens F, Wigerinck P, Andries K. Bonfanti JF, et al. Among authors: timmerman p. J Med Chem. 2008 Feb 28;51(4):875-96. doi: 10.1021/jm701284j. Epub 2008 Feb 7. J Med Chem. 2008. PMID: 18254606
Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds.
Lewi P, Arnold E, Andries K, Bohets H, Borghys H, Clark A, Daeyaert F, Das K, de Béthune MP, de Jonge M, Heeres J, Koymans L, Leempoels J, Peeters J, Timmerman P, Van den Broeck W, Vanhoutte F, Van't Klooster G, Vinkers M, Volovik Y, Janssen PA. Lewi P, et al. Among authors: timmerman p. Drugs R D. 2004;5(5):245-57. doi: 10.2165/00126839-200405050-00001. Drugs R D. 2004. PMID: 15357624
New model for intravenous drug administration and blood sampling in the awake rat, designed to increase quality and throughput for in vivo pharmacokinetic analysis.
Mackie C, Wuyts K, Haseldonckx M, Blokland S, Gysemberg P, Verhoeven I, Timmerman P, Nijsen M. Mackie C, et al. Among authors: timmerman p. J Pharmacol Toxicol Methods. 2005 Sep-Oct;52(2):293-301. doi: 10.1016/j.vascn.2004.11.002. Epub 2004 Dec 29. J Pharmacol Toxicol Methods. 2005. PMID: 16125629
179 results