Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2.
Kudrnac M, Beyl S, Hohaus A, Stary A, Peterbauer T, Timin E, Hering S.
Kudrnac M, et al. Among authors: timin e.
J Biol Chem. 2009 May 1;284(18):12276-84. doi: 10.1074/jbc.M808402200. Epub 2009 Mar 5.
J Biol Chem. 2009.
PMID: 19265197
Free PMC article.
Significant effects are induced by either proline or threonine substitutions in the lower third of segment IIS6 ("bundle crossing region"), where S6 segments are likely to seal the channel in the closed conformation (Hohaus, A., Beyl, S., Kudrnac, M., Berjukow, S., Timin, …
Significant effects are induced by either proline or threonine substitutions in the lower third of segment IIS6 ("bundle crossing region"), …