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Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial.
Chastre J, François B, Bourgeois M, Komnos A, Ferrer R, Rahav G, De Schryver N, Lepape A, Koksal I, Luyt CE, Sánchez-García M, Torres A, Eggimann P, Koulenti D, Holland TL, Ali O, Shoemaker K, Ren P, Sauser J, Ruzin A, Tabor DE, Akhgar A, Wu Y, Jiang Y, DiGiandomenico A, Colbert S, Vandamme D, Coenjaerts F, Malhotra-Kumar S, Timbermont L, Oliver A, Barraud O, Bellamy T, Bonten M, Goossens H, Reisner C, Esser MT, Jafri HS; COMBACTE-MAGNET EVADE Study Group. Chastre J, et al. Among authors: timbermont l. Crit Care. 2022 Nov 15;26(1):355. doi: 10.1186/s13054-022-04204-9. Crit Care. 2022. PMID: 36380312 Free PMC article. Clinical Trial.
Postoperative Staphylococcus aureus Infections in Patients With and Without Preoperative Colonization.
Troeman DPR, Hazard D, Timbermont L, Malhotra-Kumar S, van Werkhoven CH, Wolkewitz M, Ruzin A, Goossens H, Bonten MJM, Harbarth S, Sifakis F, Kluytmans JAJW; ASPIRE-SSI Study Team; Vlaeminck J, Vilken T, Xavier BB, Lammens C, van Esschoten M, Paling FP, Recanatini C, Coenjaerts F, Sellman B, Tkaczyk C, Weber S, Ekkelenkamp MB, van der Laan L, Vierhout BP, Couvé-Deacon E, David M, Chadwick D, Llewelyn MJ, Ustianowski A, Bateman A, Mawer D, Carevic B, Konstantinovic S, Djordjevic Z, Del Toro-López MD, Gallego JPH, Escudero D, Rojo MP, Torre-Cisneros J, Castelli F, Nardi G, Barbadoro P, Altmets M, Mitt P, Todor A, Bubenek-Turconi SI, Corneci D, Sandesc D, Gheorghita V, Brat R, Hanke I, Neumann J, Tomáš T, Laffut W, Van den Abeele AM. Troeman DPR, et al. Among authors: timbermont l. JAMA Netw Open. 2023 Oct 2;6(10):e2339793. doi: 10.1001/jamanetworkopen.2023.39793. JAMA Netw Open. 2023. PMID: 37906196 Free PMC article.
Correction: Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia.
van Engelen TSR, Reijnders TDY, Paling FP, Bonten MJM, Timbermont L, Malhotra-Kumar S, Kluytmans JAJW, Peters-Sengers H, van der Poll T; ASPIRE-I. C. U. Study Team. van Engelen TSR, et al. Among authors: timbermont l. Crit Care. 2023 Nov 1;27(1):420. doi: 10.1186/s13054-023-04700-6. Crit Care. 2023. PMID: 37915039 Free PMC article. No abstract available.
Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients.
Diaz Caballero J, Wheatley RM, Kapel N, López-Causapé C, Van der Schalk T, Quinn A, Shaw LP, Ogunlana L, Recanatini C, Xavier BB, Timbermont L, Kluytmans J, Ruzin A, Esser M, Malhotra-Kumar S, Oliver A, MacLean RC. Diaz Caballero J, et al. Among authors: timbermont l. Nat Commun. 2023 Jul 12;14(1):4083. doi: 10.1038/s41467-023-39416-2. Nat Commun. 2023. PMID: 37438338 Free PMC article.
Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient.
Wheatley RM, Caballero JD, van der Schalk TE, De Winter FHR, Shaw LP, Kapel N, Recanatini C, Timbermont L, Kluytmans J, Esser M, Lacoma A, Prat-Aymerich C, Oliver A, Kumar-Singh S, Malhotra-Kumar S, Craig MacLean R. Wheatley RM, et al. Among authors: timbermont l. Nat Commun. 2022 Nov 22;13(1):6523. doi: 10.1038/s41467-022-34101-2. Nat Commun. 2022. PMID: 36414617 Free PMC article.
Susceptibility profiles and resistance genomics of Pseudomonas aeruginosa isolates from European ICUs participating in the ASPIRE-ICU trial.
Torrens G, van der Schalk TE, Cortes-Lara S, Timbermont L, Del Barrio-Tofiño E, Xavier BB, Zamorano L, Lammens C, Ali O, Ruzin A, Goossens H, Kumar-Singh S, Kluytmans J, Paling F, MacLean RC, Köhler T, López-Causapé C, Malhotra-Kumar S, Oliver A; ASPIRE-ICU study team. Torrens G, et al. Among authors: timbermont l. J Antimicrob Chemother. 2022 Jun 29;77(7):1862-1872. doi: 10.1093/jac/dkac122. J Antimicrob Chemother. 2022. PMID: 35451008 Clinical Trial.
Evaluation of GeneXpert PA assay compared to genomic and (semi-)quantitative culture methods for direct detection of Pseudomonas aeruginosa in endotracheal aspirates.
van der Schalk TE, Coppens J, Timbermont L, Turlej-Rogacka A, Van Heirstraeten L, Berkell M, Yu L, Lammens C, Xavier BB, Matheeussen V, Ieven M, McCarthy M, Jorens PG, Ruzin A, Esser MT, Kumar-Singh S, Goossens H, Malhotra-Kumar S. van der Schalk TE, et al. Among authors: timbermont l. Antimicrob Resist Infect Control. 2021 Jul 23;10(1):110. doi: 10.1186/s13756-021-00978-9. Antimicrob Resist Infect Control. 2021. PMID: 34301343 Free PMC article.
44 results