Tikhonova IG - Search Results

1

Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists.

Mahindra A, Jenkins L, Marsango S, Huggett M, Huggett M, Robinson L, Gillespie J, Rajamanickam M, Morrison A, McElroy S, Tikhonova IG, Milligan G, Jamieson AG. Mahindra A, et al. Among authors: tikhonova ig. J Med Chem. 2022 Aug 25;65(16):11270-11290. doi: 10.1021/acs.jmedchem.2c00804. Epub 2022 Aug 10. J Med Chem. 2022. PMID: 35948061 Free PMC article.

2

Structural basis for understanding structure-activity relationships for the glutamate binding site of the NMDA receptor.

Tikhonova IG, Baskin II, Palyulin VA, Zefirov NS, Bachurin SO. Tikhonova IG, et al. J Med Chem. 2002 Aug 29;45(18):3836-43. doi: 10.1021/jm011091t. J Med Chem. 2002. PMID: 12190307

3

CoMFA and homology-based models of the glycine binding site of N-methyl-d-aspartate receptor.

Tikhonova IG, Baskin II, Palyulin VA, Zefirov NS. Tikhonova IG, et al. J Med Chem. 2003 Apr 24;46(9):1609-16. doi: 10.1021/jm0210156. J Med Chem. 2003. PMID: 12699379

4

Selectivity fields: comparative molecular field analysis (CoMFA) of the glycine/NMDA and AMPA receptors.

Baskin II, Tikhonova IG, Palyulin VA, Zefirov NS. Baskin II, et al. Among authors: tikhonova ig. J Med Chem. 2003 Sep 11;46(19):4063-9. doi: 10.1021/jm030833a. J Med Chem. 2003. PMID: 12954059

5

Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor.

Archer-Lahlou E, Tikhonova I, Escrieut C, Dufresne M, Seva C, Pradayrol L, Moroder L, Maigret B, Fourmy D. Archer-Lahlou E, et al. J Med Chem. 2005 Jan 13;48(1):180-91. doi: 10.1021/jm049886y. J Med Chem. 2005. PMID: 15634012

6

P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring.

Costanzi S, Tikhonova IG, Ohno M, Roh EJ, Joshi BV, Colson AO, Houston D, Maddileti S, Harden TK, Jacobson KA. Costanzi S, et al. Among authors: tikhonova ig. J Med Chem. 2007 Jul 12;50(14):3229-41. doi: 10.1021/jm0700971. Epub 2007 Jun 12. J Med Chem. 2007. PMID: 17564423

7

Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening.

Tikhonova IG, Sum CS, Neumann S, Engel S, Raaka BM, Costanzi S, Gershengorn MC. Tikhonova IG, et al. J Med Chem. 2008 Feb 14;51(3):625-33. doi: 10.1021/jm7012425. Epub 2008 Jan 15. J Med Chem. 2008. PMID: 18193825 Free PMC article.

8

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.

Schmidt J, Smith NJ, Christiansen E, Tikhonova IG, Grundmann M, Hudson BD, Ward RJ, Drewke C, Milligan G, Kostenis E, Ulven T. Schmidt J, et al. Among authors: tikhonova ig. J Biol Chem. 2011 Mar 25;286(12):10628-40. doi: 10.1074/jbc.M110.210872. Epub 2011 Jan 10. J Biol Chem. 2011. PMID: 21220428 Free PMC article.

9

Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.

Chen X, Tikhonova IG, Decker M. Chen X, et al. Among authors: tikhonova ig. Bioorg Med Chem. 2011 Feb 1;19(3):1222-35. doi: 10.1016/j.bmc.2010.12.034. Epub 2010 Dec 21. Bioorg Med Chem. 2011. PMID: 21232964

10

Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.

Smith NJ, Ward RJ, Stoddart LA, Hudson BD, Kostenis E, Ulven T, Morris JC, Tränkle C, Tikhonova IG, Adams DR, Milligan G. Smith NJ, et al. Among authors: tikhonova ig. Mol Pharmacol. 2011 Jul;80(1):163-73. doi: 10.1124/mol.110.070789. Epub 2011 Apr 15. Mol Pharmacol. 2011. PMID: 21498659 Free PMC article.

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