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Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity.
Polianskyte-Prause Z, Tolvanen TA, Lindfors S, Dumont V, Van M, Wang H, Dash SN, Berg M, Naams JB, Hautala LC, Nisen H, Mirtti T, Groop PH, Wähälä K, Tienari J, Lehtonen S. Polianskyte-Prause Z, et al. Among authors: tienari j. FASEB J. 2019 Feb;33(2):2858-2869. doi: 10.1096/fj.201800529RR. Epub 2018 Oct 15. FASEB J. 2019. PMID: 30321069 Free PMC article.
Ezrin is down-regulated in diabetic kidney glomeruli and regulates actin reorganization and glucose uptake via GLUT1 in cultured podocytes.
Wasik AA, Koskelainen S, Hyvönen ME, Musante L, Lehtonen E, Koskenniemi K, Tienari J, Vaheri A, Kerjaschki D, Szalay C, Révész C, Varmanen P, Nyman TA, Hamar P, Holthöfer H, Lehtonen S. Wasik AA, et al. Among authors: tienari j. Am J Pathol. 2014 Jun;184(6):1727-39. doi: 10.1016/j.ajpath.2014.03.002. Epub 2014 Apr 13. Am J Pathol. 2014. PMID: 24726496
Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway.
Saurus P, Kuusela S, Lehtonen E, Hyvönen ME, Ristola M, Fogarty CL, Tienari J, Lassenius MI, Forsblom C, Lehto M, Saleem MA, Groop PH, Holthöfer H, Lehtonen S. Saurus P, et al. Among authors: tienari j. Cell Death Dis. 2015 May 7;6(5):e1752. doi: 10.1038/cddis.2015.125. Cell Death Dis. 2015. PMID: 25950482 Free PMC article.
37 results