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Page 1
CXCL4 drives fibrosis by promoting several key cellular and molecular processes.
Affandi AJ, Carvalheiro T, Ottria A, de Haan JJ, Brans MAD, Brandt MM, Tieland RG, Lopes AP, Fernández BM, Bekker CPJ, van der Linden M, Zimmermann M, Giovannone B, Wichers CGK, Garcia S, de Kok M, Stifano G, Xu YJ, Kowalska MA, Waasdorp M, Cheng C, Gibbs S, de Jager SCA, van Roon JAG, Radstake TRDJ, Marut W. Affandi AJ, et al. Among authors: tieland rg. Cell Rep. 2022 Jan 4;38(1):110189. doi: 10.1016/j.celrep.2021.110189. Cell Rep. 2022. PMID: 34986347 Free article.
Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis.
Affandi AJ, Carvalheiro T, Ottria A, Broen JC, Bossini-Castillo L, Tieland RG, Bon LV, Chouri E, Rossato M, Mertens JS, Garcia S, Pandit A, de Kroon LM, Christmann RB, Martin J, van Roon JA, Radstake TR, Marut W. Affandi AJ, et al. Among authors: tieland rg. Ann Rheum Dis. 2019 Sep;78(9):1249-1259. doi: 10.1136/annrheumdis-2018-214991. Epub 2019 May 24. Ann Rheum Dis. 2019. PMID: 31126957
Fatty Acid and Carnitine Metabolism Are Dysregulated in Systemic Sclerosis Patients.
Ottria A, Hoekstra AT, Zimmermann M, van der Kroef M, Vazirpanah N, Cossu M, Chouri E, Rossato M, Beretta L, Tieland RG, Wichers CGK, Stigter E, Gulersonmez C, Bonte-Mineur F, Berkers CR, Radstake TRDJ, Marut W. Ottria A, et al. Among authors: tieland rg. Front Immunol. 2020 May 22;11:822. doi: 10.3389/fimmu.2020.00822. eCollection 2020. Front Immunol. 2020. PMID: 32528464 Free PMC article.
Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α.
Ottria A, Zimmermann M, Paardekooper LM, Carvalheiro T, Vazirpanah N, Silva-Cardoso S, Affandi AJ, Chouri E, V D Kroef M, Tieland RG, Bekker CPJ, Wichers CGK, Rossato M, Mocholi-Gimeno E, Tekstra J, Ton E, van Laar JM, Cossu M, Beretta L, Garcia Perez S, Pandit A, Bonte-Mineur F, Reedquist KA, van den Bogaart G, Radstake TRDJ, Marut W. Ottria A, et al. Among authors: tieland rg. Rheumatology (Oxford). 2022 May 30;61(6):2682-2693. doi: 10.1093/rheumatology/keab532. Rheumatology (Oxford). 2022. PMID: 34559222
Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis.
Carvalheiro T, Marut W, Pascoal Ramos MI, García S, Fleury D, Affandi AJ, Meijers AS, Giovannone B, Tieland RG, Elshof E, Ottria A, Cossu M, Meizlish ML, Veenendaal T, Ramanujam M, Moreno-García ME, Klumperman J, Liv N, Radstake TRDJ, Meyaard L. Carvalheiro T, et al. Among authors: tieland rg. J Autoimmun. 2024 May 1;146:103219. doi: 10.1016/j.jaut.2024.103219. Online ahead of print. J Autoimmun. 2024. PMID: 38696927 Free article.