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"Affimer" synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation.
Roper BWR, Tiede C, Abdul-Zani I, Cuthbert GA, Jade D, Al-Aufi A, Critchley WR, Saikia Q, Homer-Vanniasinkam S, Sawamura T, McPherson MJ, Harrison MA, Tomlinson DC, Ponnambalam S. Roper BWR, et al. Among authors: tiede c. J Biol Chem. 2023 Nov;299(11):105325. doi: 10.1016/j.jbc.2023.105325. Epub 2023 Oct 5. J Biol Chem. 2023. PMID: 37805141 Free PMC article.
Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Hughes DJ, Tiede C, Penswick N, Tang AA, Trinh CH, Mandal U, Zajac KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC, Whitehouse A. Hughes DJ, et al. Among authors: tiede c. Sci Signal. 2017 Nov 14;10(505):eaaj2005. doi: 10.1126/scisignal.aaj2005. Sci Signal. 2017. PMID: 29138295 Free PMC article.
Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action.
Robinson JI, Baxter EW, Owen RL, Thomsen M, Tomlinson DC, Waterhouse MP, Win SJ, Nettleship JE, Tiede C, Foster RJ, Owens RJ, Fishwick CWG, Harris SA, Goldman A, McPherson MJ, Morgan AW. Robinson JI, et al. Among authors: tiede c. Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E72-E81. doi: 10.1073/pnas.1707856115. Epub 2017 Dec 15. Proc Natl Acad Sci U S A. 2018. PMID: 29247053 Free PMC article.
Affinity purification of fibrinogen using an Affimer column.
Pechlivani N, Kearney KJ, Tiede C, Cheah R, Phoenix F, Ponnambalam S, Ault JR, McPherson MJ, Tomlinson DC, Ajjan RA. Pechlivani N, et al. Among authors: tiede c. Biochim Biophys Acta Gen Subj. 2022 May;1866(5):130115. doi: 10.1016/j.bbagen.2022.130115. Epub 2022 Feb 28. Biochim Biophys Acta Gen Subj. 2022. PMID: 35240235 Free article.
Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications.
Kearney KJ, Pechlivani N, King R, Tiede C, Phoenix F, Cheah R, Macrae FL, Simmons KJ, Manfield IW, Smith KA, Spurgeon BEJ, Naseem KM, Ariens RAS, McPherson MJ, Tomlinson DC, Ajjan RA. Kearney KJ, et al. Among authors: tiede c. Blood. 2019 Mar 14;133(11):1233-1244. doi: 10.1182/blood-2018-06-856195. Epub 2018 Dec 13. Blood. 2019. PMID: 30545831 Free PMC article.
45 results