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Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models.
Kuta R, Larochelle N, Fernandez M, Pal A, Minotti S, Tibshirani M, St Louis K, Gentil BJ, Nalbantoglu JN, Hermann A, Durham HD. Kuta R, et al. Among authors: tibshirani m. Cell Stress Chaperones. 2020 Jan;25(1):173-191. doi: 10.1007/s12192-019-01064-1. Epub 2020 Jan 3. Cell Stress Chaperones. 2020. PMID: 31900865 Free PMC article.