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Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance.
Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio CM, Dai SA, Dickinson MS, Elledge SK, Helsell CVM, Hendel NL, Kang E, Kern N, Khoroshkin MS, Kirkemo LL, Lewis GR, Lou K, Marin WM, Maxwell AM, McTigue PF, Myers-Turnbull D, Nagy TL, Natale AM, Oltion K, Pourmal S, Reder GK, Rettko NJ, Rohweder PJ, Schwarz DMC, Tan SK, Thomas PV, Tibble RW, Town JP, Tsai MK, Ugur FS, Wassarman DR, Wolff AM, Wu TS, Bogdanoff D, Li J, Thorn KS, O'Conchúir S, Swaney DL, Chow ED, Madhani HD, Redding S, Bolon DN, Kortemme T, DeRisi JL, Kampmann M, Fraser JS. Mavor D, et al. Among authors: tibble rw. Biol Open. 2018 Jul 23;7(7):bio036103. doi: 10.1242/bio.036103. Biol Open. 2018. PMID: 30037883 Free PMC article.
Control of mRNA decapping by autoinhibition.
Paquette DR, Tibble RW, Daifuku TS, Gross JD. Paquette DR, et al. Among authors: tibble rw. Nucleic Acids Res. 2018 Jul 6;46(12):6318-6329. doi: 10.1093/nar/gky233. Nucleic Acids Res. 2018. PMID: 29618050 Free PMC article.
HP1 reshapes nucleosome core to promote phase separation of heterochromatin.
Sanulli S, Trnka MJ, Dharmarajan V, Tibble RW, Pascal BD, Burlingame AL, Griffin PR, Gross JD, Narlikar GJ. Sanulli S, et al. Among authors: tibble rw. Nature. 2019 Nov;575(7782):390-394. doi: 10.1038/s41586-019-1669-2. Epub 2019 Oct 16. Nature. 2019. PMID: 31618757 Free PMC article.
Pat1 activates late steps in mRNA decay by multiple mechanisms.
Lobel JH, Tibble RW, Gross JD. Lobel JH, et al. Among authors: tibble rw. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23512-23517. doi: 10.1073/pnas.1905455116. Epub 2019 Nov 5. Proc Natl Acad Sci U S A. 2019. PMID: 31690658 Free PMC article.
Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect.
Warminski M, Kowalska J, Nowak E, Kubacka D, Tibble R, Kasprzyk R, Sikorski PJ, Gross JD, Nowotny M, Jemielity J. Warminski M, et al. ACS Chem Biol. 2021 Feb 19;16(2):334-343. doi: 10.1021/acschembio.0c00864. Epub 2021 Jan 13. ACS Chem Biol. 2021. PMID: 33439620 Free PMC article.
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