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Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains.
Jian J, Zhao S, Tian Q, Gonzalez-Gugel E, Mundra JJ, Uddin SM, Liu B, Richbourgh B, Brunetti R, Liu CJ. Jian J, et al. Among authors: tian q. FEBS Lett. 2013 Nov 1;587(21):3428-36. doi: 10.1016/j.febslet.2013.09.024. Epub 2013 Sep 23. FEBS Lett. 2013. PMID: 24070898 Free PMC article.
Progranulin inhibition of TNFα.
Uddin SM, Mundra JJ, Jian J, Tian Q, Gonzalez-Gugel E, Richbourgh B, Liu CJ. Uddin SM, et al. Among authors: tian q. Immunol Cell Biol. 2014 Apr;92(4):299-300. doi: 10.1038/icb.2014.7. Epub 2014 Feb 11. Immunol Cell Biol. 2014. PMID: 24518982 No abstract available.
The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.
Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ. Tang W, et al. Among authors: tian qy. Science. 2011 Apr 22;332(6028):478-84. doi: 10.1126/science.1199214. Epub 2011 Mar 10. Science. 2011. PMID: 21393509 Free PMC article.
3,200 results