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Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.
Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L. Unger EK, et al. Among authors: tian l. Cell. 2020 Dec 23;183(7):1986-2002.e26. doi: 10.1016/j.cell.2020.11.040. Epub 2020 Dec 16. Cell. 2020. PMID: 33333022 Free PMC article.
Psychedelic-inspired drug discovery using an engineered biosensor.
Dong C, Ly C, Dunlap LE, Vargas MV, Sun J, Hwang IW, Azinfar A, Oh WC, Wetsel WC, Olson DE, Tian L. Dong C, et al. Among authors: tian l. Cell. 2021 May 13;184(10):2779-2792.e18. doi: 10.1016/j.cell.2021.03.043. Epub 2021 Apr 28. Cell. 2021. PMID: 33915107 Free PMC article.
Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors.
Patriarchi T, Cho JR, Merten K, Howe MW, Marley A, Xiong WH, Folk RW, Broussard GJ, Liang R, Jang MJ, Zhong H, Dombeck D, von Zastrow M, Nimmerjahn A, Gradinaru V, Williams JT, Tian L. Patriarchi T, et al. Among authors: tian l. Science. 2018 Jun 29;360(6396):eaat4422. doi: 10.1126/science.aat4422. Epub 2018 May 31. Science. 2018. PMID: 29853555 Free PMC article.
An expanded palette of dopamine sensors for multiplex imaging in vivo.
Patriarchi T, Mohebi A, Sun J, Marley A, Liang R, Dong C, Puhger K, Mizuno GO, Davis CM, Wiltgen B, von Zastrow M, Berke JD, Tian L. Patriarchi T, et al. Among authors: tian l. Nat Methods. 2020 Nov;17(11):1147-1155. doi: 10.1038/s41592-020-0936-3. Epub 2020 Sep 7. Nat Methods. 2020. PMID: 32895537 Free PMC article.
An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice.
Zhang JF, Liu B, Hong I, Mo A, Roth RH, Tenner B, Lin W, Zhang JZ, Molina RS, Drobizhev M, Hughes TE, Tian L, Huganir RL, Mehta S, Zhang J. Zhang JF, et al. Among authors: tian l. Nat Chem Biol. 2021 Jan;17(1):39-46. doi: 10.1038/s41589-020-00660-y. Epub 2020 Sep 28. Nat Chem Biol. 2021. PMID: 32989297 Free PMC article.
Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition.
Abraham AD, Casello SM, Schattauer SS, Wong BA, Mizuno GO, Mahe K, Tian L, Land BB, Chavkin C. Abraham AD, et al. Among authors: tian l. Neuropsychopharmacology. 2021 Dec;46(13):2330-2339. doi: 10.1038/s41386-021-01168-2. Epub 2021 Sep 20. Neuropsychopharmacology. 2021. PMID: 34545197 Free PMC article.
8,025 results