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Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models.
Orvain C, Cauvet A, Prudent A, Guignabert C, Thuillet R, Ottaviani M, Tu L, Duhalde F, Nicco C, Batteux F, Avouac J, Wang N, Seaberg MA, Dillon SR, Allanore Y. Orvain C, et al. Among authors: thuillet r. Arthritis Res Ther. 2022 Jan 5;24(1):13. doi: 10.1186/s13075-021-02709-2. Arthritis Res Ther. 2022. PMID: 34986869 Free PMC article.
Driving Role of Interleukin-2-Related Regulatory CD4+ T Cell Deficiency in the Development of Lung Fibrosis and Vascular Remodeling in a Mouse Model of Systemic Sclerosis.
Frantz C, Cauvet A, Durand A, Gonzalez V, Pierre R, Do Cruzeiro M, Bailly K, Andrieu M, Orvain C, Avouac J, Ottaviani M, Thuillet R, Tu L, Guignabert C, Lucas B, Auffray C, Allanore Y. Frantz C, et al. Among authors: thuillet r. Arthritis Rheumatol. 2022 Aug;74(8):1387-1398. doi: 10.1002/art.42111. Epub 2022 Jun 28. Arthritis Rheumatol. 2022. PMID: 35255201
Neutralization of CXCL12 attenuates established pulmonary hypertension in rats.
Bordenave J, Thuillet R, Tu L, Phan C, Cumont A, Marsol C, Huertas A, Savale L, Hibert M, Galzi JL, Bonnet D, Humbert M, Frossard N, Guignabert C. Bordenave J, et al. Among authors: thuillet r. Cardiovasc Res. 2020 Mar 1;116(3):686-697. doi: 10.1093/cvr/cvz153. Cardiovasc Res. 2020. PMID: 31173066
Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle-like cells in pulmonary hypertension.
Ricard N, Tu L, Le Hiress M, Huertas A, Phan C, Thuillet R, Sattler C, Fadel E, Seferian A, Montani D, Dorfmüller P, Humbert M, Guignabert C. Ricard N, et al. Among authors: thuillet r. Circulation. 2014 Apr 15;129(15):1586-97. doi: 10.1161/CIRCULATIONAHA.113.007469. Epub 2014 Jan 30. Circulation. 2014. PMID: 24481949
37 results