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Beneath the surface: endosomal GPCR signaling.
Flores-Espinoza E, Thomsen ARB. Flores-Espinoza E, et al. Among authors: thomsen arb. Trends Biochem Sci. 2024 Apr 19:S0968-0004(24)00072-0. doi: 10.1016/j.tibs.2024.03.006. Online ahead of print. Trends Biochem Sci. 2024. PMID: 38643023 Review.
Neuropilin-1 is a co-receptor for NGF and TrkA-evoked pain.
Peach CJ, Tonello R, Gomez K, Calderon-Rivera A, Bruni R, Bansia H, Maile L, Manu AM, Hahn H, Thomsen ARB, Schmidt BL, Davidson S, des Georges A, Khanna R, Bunnett NW. Peach CJ, et al. Among authors: thomsen arb. bioRxiv [Preprint]. 2024 Mar 20:2023.12.06.570398. doi: 10.1101/2023.12.06.570398. bioRxiv. 2024. PMID: 38106002 Free PMC article. Preprint.
Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief.
Hegron A, Peach CJ, Tonello R, Seemann P, Teng S, Latorre R, Huebner H, Weikert D, Rientjes J, Veldhuis NA, Poole DP, Jensen DD, Thomsen ARB, Schmidt BL, Imlach WL, Gmeiner P, Bunnett NW. Hegron A, et al. Among authors: thomsen arb. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2220979120. doi: 10.1073/pnas.2220979120. Epub 2023 May 22. Proc Natl Acad Sci U S A. 2023. PMID: 37216510 Free PMC article.
Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.
Nguyen AH, Thomsen ARB, Cahill TJ 3rd, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J 4th, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ. Nguyen AH, et al. Among authors: thomsen arb. Nat Struct Mol Biol. 2019 Dec;26(12):1123-1131. doi: 10.1038/s41594-019-0330-y. Epub 2019 Nov 18. Nat Struct Mol Biol. 2019. PMID: 31740855 Free PMC article.
Therapeutic Targeting of Endosomal G-Protein-Coupled Receptors.
Thomsen ARB, Jensen DD, Hicks GA, Bunnett NW. Thomsen ARB, et al. Trends Pharmacol Sci. 2018 Oct;39(10):879-891. doi: 10.1016/j.tips.2018.08.003. Epub 2018 Sep 1. Trends Pharmacol Sci. 2018. PMID: 30180973 Free PMC article. Review.
25 results