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DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts.
Richards LA, Kumari A, Knezevic K, Thoms JA, von Jonquieres G, Napier CE, Ali Z, O'Brien R, Marks-Bluth J, Maritz MF, Pickett HA, Morris J, Pimanda JE, MacKenzie KL. Richards LA, et al. Among authors: thoms ja. Haematologica. 2020 Jun;105(6):1517-1526. doi: 10.3324/haematol.2018.215699. Epub 2019 Aug 14. Haematologica. 2020. PMID: 31413099 Free PMC article.
ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer.
Thoms JA, Birger Y, Foster S, Knezevic K, Kirschenbaum Y, Chandrakanthan V, Jonquieres G, Spensberger D, Wong JW, Oram SH, Kinston SJ, Groner Y, Lock R, MacKenzie KL, Göttgens B, Izraeli S, Pimanda JE. Thoms JA, et al. Blood. 2011 Jun 30;117(26):7079-89. doi: 10.1182/blood-2010-12-317990. Epub 2011 May 2. Blood. 2011. PMID: 21536859 Free article.
Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia.
Diffner E, Beck D, Gudgin E, Thoms JA, Knezevic K, Pridans C, Foster S, Goode D, Lim WK, Boelen L, Metzeler KH, Micklem G, Bohlander SK, Buske C, Burnett A, Ottersbach K, Vassiliou GS, Olivier J, Wong JW, Göttgens B, Huntly BJ, Pimanda JE. Diffner E, et al. Among authors: thoms ja. Blood. 2013 Mar 21;121(12):2289-300. doi: 10.1182/blood-2012-07-446120. Epub 2013 Jan 17. Blood. 2013. PMID: 23327922 Free article.
OncoCis: annotation of cis-regulatory mutations in cancer.
Perera D, Chacon D, Thoms JA, Poulos RC, Shlien A, Beck D, Campbell PJ, Pimanda JE, Wong JW. Perera D, et al. Among authors: thoms ja. Genome Biol. 2014;15(10):485. doi: 10.1186/s13059-014-0485-0. Genome Biol. 2014. PMID: 25298093 Free PMC article.
Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias.
Tursky ML, Beck D, Thoms JA, Huang Y, Kumari A, Unnikrishnan A, Knezevic K, Evans K, Richards LA, Lee E, Morris J, Goldberg L, Izraeli S, Wong JW, Olivier J, Lock RB, MacKenzie KL, Pimanda JE. Tursky ML, et al. Among authors: thoms ja. Leukemia. 2015 Apr;29(4):819-27. doi: 10.1038/leu.2014.299. Epub 2014 Oct 13. Leukemia. 2015. PMID: 25306899
35 results