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Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.
Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, Wambaugh JF, Thomas RS. Rotroff DM, et al. Among authors: thomas rs. Toxicol Sci. 2010 Oct;117(2):348-58. doi: 10.1093/toxsci/kfq220. Epub 2010 Jul 16. Toxicol Sci. 2010. PMID: 20639261 Free PMC article.
Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays.
Wetmore BA, Wambaugh JF, Ferguson SS, Li L, Clewell HJ 3rd, Judson RS, Freeman K, Bao W, Sochaski MA, Chu TM, Black MB, Healy E, Allen B, Andersen ME, Wolfinger RD, Thomas RS. Wetmore BA, et al. Among authors: thomas rs. Toxicol Sci. 2013 Apr;132(2):327-46. doi: 10.1093/toxsci/kft012. Epub 2013 Jan 28. Toxicol Sci. 2013. PMID: 23358191
Toxicokinetic Triage for Environmental Chemicals.
Wambaugh JF, Wetmore BA, Pearce R, Strope C, Goldsmith R, Sluka JP, Sedykh A, Tropsha A, Bosgra S, Shah I, Judson R, Thomas RS, Setzer RW. Wambaugh JF, et al. Among authors: thomas rs. Toxicol Sci. 2015 Sep;147(1):55-67. doi: 10.1093/toxsci/kfv118. Epub 2015 Jun 16. Toxicol Sci. 2015. PMID: 26085347 Free PMC article.
Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.
Wetmore BA, Wambaugh JF, Allen B, Ferguson SS, Sochaski MA, Setzer RW, Houck KA, Strope CL, Cantwell K, Judson RS, LeCluyse E, Clewell HJ, Thomas RS, Andersen ME. Wetmore BA, et al. Among authors: thomas rs. Toxicol Sci. 2015 Nov;148(1):121-36. doi: 10.1093/toxsci/kfv171. Epub 2015 Aug 6. Toxicol Sci. 2015. PMID: 26251325 Free PMC article.
Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.
Shah I, Setzer RW, Jack J, Houck KA, Judson RS, Knudsen TB, Liu J, Martin MT, Reif DM, Richard AM, Thomas RS, Crofton KM, Dix DJ, Kavlock RJ. Shah I, et al. Among authors: thomas rs. Environ Health Perspect. 2016 Jul;124(7):910-9. doi: 10.1289/ehp.1409029. Epub 2015 Oct 16. Environ Health Perspect. 2016. PMID: 26473631 Free PMC article.
Cellular tipping points could be used to define a point of departure for risk-based prioritization of environmental chemicals. CITATION: Shah I, Setzer RW, Jack J, Houck KA, Judson RS, Knudsen TB, Liu J, Martin MT, Reif DM, Richard AM, Thomas RS, Crofton KM, …
Cellular tipping points could be used to define a point of departure for risk-based prioritization of environmental chemicals. CITATION: Sha …
288 results