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IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells.
Nachmias B, Khan DH, Voisin V, Mer AS, Thomas GE, Segev N, St-Germain J, Hurren R, Gronda M, Botham A, Wang X, Maclean N, Seneviratne AK, Duong N, Xu C, Arruda A, Orouji E, Algouneh A, Hakem R, Shlush L, Minden MD, Raught B, Bader GD, Schimmer AD. Nachmias B, et al. Among authors: thomas ge. Leukemia. 2022 May;36(5):1283-1295. doi: 10.1038/s41375-022-01513-4. Epub 2022 Feb 12. Leukemia. 2022. PMID: 35152270 Free PMC article.
The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids.
Seneviratne AK, Xu M, Henao JJA, Fajardo VA, Hao Z, Voisin V, Xu GW, Hurren R, Kim S, MacLean N, Wang X, Gronda M, Jeyaraju D, Jitkova Y, Ketela T, Mullokandov M, Sharon D, Thomas G, Chouinard-Watkins R, Hawley JR, Schafer C, Yau HL, Khuchua Z, Aman A, Al-Awar R, Gross A, Claypool SM, Bazinet RP, Lupien M, Chan S, De Carvalho DD, Minden MD, Bader GD, Stark KD, LeBlanc P, Schimmer AD. Seneviratne AK, et al. Cell Stem Cell. 2019 Apr 4;24(4):621-636.e16. doi: 10.1016/j.stem.2019.02.020. Epub 2019 Mar 28. Cell Stem Cell. 2019. PMID: 30930145 Free PMC article.
The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids.
Seneviratne AK, Xu M, Aristizabal Henao JJ, Fajardo VA, Hao Z, Voisin V, Xu GW, Hurren R, Kim S, MacLean N, Wang X, Gronda M, Jeyaraju D, Jitkova Y, Ketela T, Mullokandov M, Sharon D, Thomas G, Chouinard-Watkins R, Hawley JR, Schafer C, Yau HL, Khuchua Z, Aman A, Al-Awar R, Gross A, Claypool SM, Bazinet RP, Lupien M, Chan S, De Carvalho DD, Minden MD, Bader GD, Stark KD, LeBlanc P, Schimmer AD. Seneviratne AK, et al. Cell Stem Cell. 2019 Jun 6;24(6):1007. doi: 10.1016/j.stem.2019.04.020. Cell Stem Cell. 2019. PMID: 31173706 Free article. No abstract available.
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
Singh RP, Jeyaraju DV, Voisin V, Hurren R, Xu C, Hawley JR, Barghout SH, Khan DH, Gronda M, Wang X, Jitkova Y, Sharon D, Liyanagae S, MacLean N, Seneviratene AK, Mirali S, Borenstein A, Thomas GE, Soriano J, Orouji E, Minden MD, Arruda A, Chan SM, Bader GD, Lupien M, Schimmer AD. Singh RP, et al. Among authors: thomas ge. Cell Stem Cell. 2020 Jun 4;26(6):926-937.e10. doi: 10.1016/j.stem.2020.04.010. Epub 2020 May 15. Cell Stem Cell. 2020. PMID: 32416059 Free article.
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Thomas GE, Egan G, García-Prat L, Botham A, Voisin V, Patel PS, Hoff FW, Chin J, Nachmias B, Kaufmann KB, Khan DH, Hurren R, Wang X, Gronda M, MacLean N, O'Brien C, Singh RP, Jones CL, Harding SM, Raught B, Arruda A, Minden MD, Bader GD, Hakem R, Kornblau S, Dick JE, Schimmer AD. Thomas GE, et al. Nat Cell Biol. 2022 Jun;24(6):872-884. doi: 10.1038/s41556-022-00925-9. Epub 2022 Jun 6. Nat Cell Biol. 2022. PMID: 35668135 Free PMC article.
Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase.
Jeyaraju DV, Alapa M, Polonskaia A, Risueño A, Subramanyam P, Anand A, Ghosh K, Kyriakopoulos C, Hemerich D, Hurren R, Wang X, Gronda M, Ahsan A, Chiu H, Thomas G, Lind EF, Menezes DL, Schimmer AD, Hagner PR, Gandhi A, Thakurta AG. Jeyaraju DV, et al. Haematologica. 2024 Apr 1;109(4):1082-1094. doi: 10.3324/haematol.2023.283437. Haematologica. 2024. PMID: 37941406 Free PMC article.
Towards equitable brain genomics research, for us by us.
Dzirasa K, Thomas GE, Hathaway AC Sr. Dzirasa K, et al. Among authors: thomas ge. Nat Neurosci. 2024 May 20. doi: 10.1038/s41593-024-01651-1. Online ahead of print. Nat Neurosci. 2024. PMID: 38769151 No abstract available.
112 results