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Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH. Fischer ES, et al. Among authors: thoma nh. Nature. 2014 Aug 7;512(7512):49-53. doi: 10.1038/nature13527. Epub 2014 Jul 16. Nature. 2014. PMID: 25043012 Free PMC article.
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
Scrima A, Konícková R, Czyzewski BK, Kawasaki Y, Jeffrey PD, Groisman R, Nakatani Y, Iwai S, Pavletich NP, Thomä NH. Scrima A, et al. Among authors: thoma nh. Cell. 2008 Dec 26;135(7):1213-23. doi: 10.1016/j.cell.2008.10.045. Cell. 2008. PMID: 19109893 Free PMC article.
Histone methylation by PRC2 is inhibited by active chromatin marks.
Schmitges FW, Prusty AB, Faty M, Stützer A, Lingaraju GM, Aiwazian J, Sack R, Hess D, Li L, Zhou S, Bunker RD, Wirth U, Bouwmeester T, Bauer A, Ly-Hartig N, Zhao K, Chan H, Gu J, Gut H, Fischle W, Müller J, Thomä NH. Schmitges FW, et al. Among authors: thoma nh. Mol Cell. 2011 May 6;42(3):330-41. doi: 10.1016/j.molcel.2011.03.025. Mol Cell. 2011. PMID: 21549310 Free article.
Crystal structure of the human COP9 signalosome.
Lingaraju GM, Bunker RD, Cavadini S, Hess D, Hassiepen U, Renatus M, Fischer ES, Thomä NH. Lingaraju GM, et al. Among authors: thoma nh. Nature. 2014 Aug 14;512(7513):161-5. doi: 10.1038/nature13566. Epub 2014 Jul 16. Nature. 2014. PMID: 25043011
Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein.
Matsumoto S, Fischer ES, Yasuda T, Dohmae N, Iwai S, Mori T, Nishi R, Yoshino K, Sakai W, Hanaoka F, Thomä NH, Sugasawa K. Matsumoto S, et al. Among authors: thoma nh. Nucleic Acids Res. 2015 Feb 18;43(3):1700-13. doi: 10.1093/nar/gkv038. Epub 2015 Jan 27. Nucleic Acids Res. 2015. PMID: 25628365 Free PMC article.
SPLINTS: small-molecule protein ligand interface stabilizers.
Fischer ES, Park E, Eck MJ, Thomä NH. Fischer ES, et al. Among authors: thoma nh. Curr Opin Struct Biol. 2016 Apr;37:115-22. doi: 10.1016/j.sbi.2016.01.004. Epub 2016 Jan 30. Curr Opin Struct Biol. 2016. PMID: 26829757 Free PMC article. Review.
77 results