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Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming.
Nat Commun. 2018 Aug 29;9(1):3506. doi: 10.1038/s41467-018-05861-7.
Nat Commun. 2018.
PMID: 30158636
Free PMC article.
Nrf2 Negatively Regulates Type I Interferon Responses and Increases Susceptibility to Herpes Genital Infection in Mice.
Gunderstofte C, Iversen MB, Peri S, Thielke A, Balachandran S, Holm CK, Olagnier D.
Gunderstofte C, et al.
Front Immunol. 2019 Sep 6;10:2101. doi: 10.3389/fimmu.2019.02101. eCollection 2019.
Front Immunol. 2019.
PMID: 31555293
Free PMC article.
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SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Olagnier D, Farahani E, Thyrsted J, Blay-Cadanet J, Herengt A, Idorn M, Hait A, Hernaez B, Knudsen A, Iversen MB, Schilling M, Jørgensen SE, Thomsen M, Reinert LS, Lappe M, Hoang HD, Gilchrist VH, Hansen AL, Ottosen R, Nielsen CG, Møller C, van der Horst D, Peri S, Balachandran S, Huang J, Jakobsen M, Svenningsen EB, Poulsen TB, Bartsch L, Thielke AL, Luo Y, Alain T, Rehwinkel J, Alcamí A, Hiscott J, Mogensen TH, Paludan SR, Holm CK.
Olagnier D, et al. Among authors: thielke al.
Nat Commun. 2020 Oct 2;11(1):4938. doi: 10.1038/s41467-020-18764-3.
Nat Commun. 2020.
PMID: 33009401
Free PMC article.
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Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Olagnier D, Farahani E, Thyrsted J, Blay-Cadanet J, Herengt A, Idorn M, Hait A, Hernaez B, Knudsen A, Iversen MB, Schilling M, Jørgensen SE, Thomsen M, Reinert LS, Lappe M, Hoang HD, Gilchrist VH, Hansen AL, Ottosen R, Nielsen CG, Møller C, van der Horst D, Peri S, Balachandran S, Huang J, Jakobsen M, Svenningsen EB, Poulsen TB, Bartsch L, Thielke AL, Luo Y, Alain T, Rehwinkel J, Alcamí A, Hiscott J, Mogensen TH, Paludan SR, Holm CK.
Olagnier D, et al. Among authors: thielke al.
Nat Commun. 2020 Oct 21;11(1):5419. doi: 10.1038/s41467-020-19363-y.
Nat Commun. 2020.
PMID: 33087717
Free PMC article.
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Global transcriptional changes in response to cGAMP depend on STING in human THP-1 cells.
Hansen AL, Brandtoft AM, Nyegaard M, Thielke AL, Olagnier D, Holm CK.
Hansen AL, et al. Among authors: thielke al.
Cell Mol Immunol. 2018 Nov;15(11):983-985. doi: 10.1038/s41423-018-0035-x. Epub 2018 May 16.
Cell Mol Immunol. 2018.
PMID: 29769658
Free PMC article.
No abstract available.
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Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
Hansen AL, Buchan GJ, Rühl M, Mukai K, Salvatore SR, Ogawa E, Andersen SD, Iversen MB, Thielke AL, Gunderstofte C, Motwani M, Møller CT, Jakobsen AS, Fitzgerald KA, Roos J, Lin R, Maier TJ, Goldbach-Mansky R, Miner CA, Qian W, Miner JJ, Rigby RE, Rehwinkel J, Jakobsen MR, Arai H, Taguchi T, Schopfer FJ, Olagnier D, Holm CK.
Hansen AL, et al. Among authors: thielke al.
Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7768-E7775. doi: 10.1073/pnas.1806239115. Epub 2018 Jul 30.
Proc Natl Acad Sci U S A. 2018.
PMID: 30061387
Free PMC article.
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Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium.
Thyrsted J, Storgaard J, Blay-Cadanet J, Heinz A, Thielke AL, Crotta S, de Paoli F, Olagnier D, Wack A, Hiller K, Hansen AL, Holm CK.
Thyrsted J, et al. Among authors: thielke al.
iScience. 2021 Nov 19;24(11):103300. doi: 10.1016/j.isci.2021.103300. Epub 2021 Oct 15.
iScience. 2021.
PMID: 34746710
Free PMC article.
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