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Gas6/Axl Axis Activation Dampens the Inflammatory Response in Osteoarthritic Fibroblast-like Synoviocytes and Synovial Explants.
Pharmaceuticals (Basel). 2023 May 6;16(5):703. doi: 10.3390/ph16050703.
Pharmaceuticals (Basel). 2023.
PMID: 37242486
Free PMC article.
TGFβ/BMP Signaling Pathway in Cartilage Homeostasis.
Thielen NGM, van der Kraan PM, van Caam APM.
Thielen NGM, et al.
Cells. 2019 Aug 24;8(9):969. doi: 10.3390/cells8090969.
Cells. 2019.
PMID: 31450621
Free PMC article.
Review.
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Increased IL-6 receptor expression and signaling in ageing cartilage can be explained by loss of TGF-β-mediated IL-6 receptor suppression.
Wiegertjes R, Thielen NGM, van Caam APM, van Laar M, van Beuningen HM, Koenders MI, van Lent PLEM, van der Kraan PM, van de Loo FAJ, Blaney Davidson EN.
Wiegertjes R, et al. Among authors: thielen ngm.
Osteoarthritis Cartilage. 2021 May;29(5):773-782. doi: 10.1016/j.joca.2021.01.008. Epub 2021 Feb 20.
Osteoarthritis Cartilage. 2021.
PMID: 33617971
Free article.
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Osteoarthritis-Related Inflammation Blocks TGF-β's Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region.
Thielen N, Neefjes M, Wiegertjes R, van den Akker G, Vitters E, van Beuningen H, Blaney Davidson E, Koenders M, van Lent P, van de Loo F, van Caam A, van der Kraan P.
Thielen N, et al.
Int J Mol Sci. 2021 Jul 29;22(15):8124. doi: 10.3390/ijms22158124.
Int J Mol Sci. 2021.
PMID: 34360888
Free PMC article.
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Identification of Transcription Factors Responsible for a Transforming Growth Factor-β-Driven Hypertrophy-like Phenotype in Human Osteoarthritic Chondrocytes.
Thielen NGM, Neefjes M, Vitters EL, van Beuningen HM, Blom AB, Koenders MI, van Lent PLEM, van de Loo FAJ, Blaney Davidson EN, van Caam APM, van der Kraan PM.
Thielen NGM, et al.
Cells. 2022 Apr 5;11(7):1232. doi: 10.3390/cells11071232.
Cells. 2022.
PMID: 35406794
Free PMC article.
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Separating friend from foe: Inhibition of TGF-β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes.
Thielen NGM, van Caam APM, V Beuningen HM, Vitters EL, van den Bosch MHJ, Koenders MI, van de Loo FAJ, Blaney Davidson EN, van der Kraan PM.
Thielen NGM, et al.
Osteoarthritis Cartilage. 2023 Nov;31(11):1481-1490. doi: 10.1016/j.joca.2023.08.004. Epub 2023 Aug 29.
Osteoarthritis Cartilage. 2023.
PMID: 37652257
Free article.
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Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation.
Ceelen JJM, Schols AMWJ, Thielen NGM, Haegens A, Gray DA, Kelders MCJM, de Theije CC, Langen RCJ.
Ceelen JJM, et al. Among authors: thielen ngm.
Respir Res. 2018 May 2;19(1):80. doi: 10.1186/s12931-018-0753-8.
Respir Res. 2018.
PMID: 29720191
Free PMC article.
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