Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

40 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
Pyrrolizidine alkaloids in food and phytomedicine: Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review.
Schrenk D, Gao L, Lin G, Mahony C, Mulder PPJ, Peijnenburg A, Pfuhler S, Rietjens IMCM, Rutz L, Steinhoff B, These A. Schrenk D, et al. Among authors: these a. Food Chem Toxicol. 2020 Feb;136:111107. doi: 10.1016/j.fct.2019.111107. Epub 2020 Jan 3. Food Chem Toxicol. 2020. PMID: 31904473 Review.
Among naturally occurring plant constituents, the 1,2-unsaturated pyrrolizidine alkaloids (in the following termed 'PAs') play a distinct role because of the large number of congeners occurring in nature and the pronounced toxicity of some congeners. ...The contributions i …
Among naturally occurring plant constituents, the 1,2-unsaturated pyrrolizidine alkaloids (in the following termed 'PAs') play a dist …
Determination of pyrrolizidine alkaloids in tea, herbal drugs and honey.
Bodi D, Ronczka S, Gottschalk C, Behr N, Skibba A, Wagner M, Lahrssen-Wiederholt M, Preiss-Weigert A, These A. Bodi D, et al. Among authors: these a. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(11):1886-95. doi: 10.1080/19440049.2014.964337. Epub 2014 Oct 9. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014. PMID: 25222912
Results suggest that PA in tea samples are most likely a contamination caused by co-harvesting of PA-producing plants. In some cases such as fennel, anise or caraway, it cannot be excluded that these plants are able to produce PA themselves....
Results suggest that PA in tea samples are most likely a contamination caused by co-harvesting of PA-producing plants. In some cases …
Occurrence of pyrrolizidine alkaloids in animal- and plant-derived food: results of a survey across Europe.
Mulder PPJ, López P, Castellari M, Bodi D, Ronczka S, Preiss-Weigert A, These A. Mulder PPJ, et al. Among authors: these a. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Jan;35(1):118-133. doi: 10.1080/19440049.2017.1382726. Epub 2017 Oct 17. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018. PMID: 28942718
Recent investigations revealed their frequent occurrence in honey and particularly in tea. To obtain a comprehensive overview of the PA content in animal- and plant-derived food from the European market, and to provide a basis for future risk analysis, a tota …
Recent investigations revealed their frequent occurrence in honey and particularly in tea. To obtain a comprehensive overview of the …
Pyrrolizidine alkaloid profiling of four Boraginaceae species from Northern Germany and implications for the analytical scope proposed for monitoring of maximum levels.
Mädge I, Gehling M, Schöne C, Winterhalter P, These A. Mädge I, et al. Among authors: these a. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2020 Aug;37(8):1339-1358. doi: 10.1080/19440049.2020.1757166. Epub 2020 May 21. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2020. PMID: 32436779
In vitro biotransformation of pyrrolizidine alkaloids in different species: part II-identification and quantitative assessment of the metabolite profile of six structurally different pyrrolizidine alkaloids.
Geburek I, Schrenk D, These A. Geburek I, et al. Among authors: these a. Arch Toxicol. 2020 Nov;94(11):3759-3774. doi: 10.1007/s00204-020-02853-9. Epub 2020 Sep 3. Arch Toxicol. 2020. PMID: 32880719 Free PMC article.
In addition, all diester PAs formed several dehydrogenation products, via the insertion of a second double bond in the necine base, including the formation of glutathione conjugates. In rat liver microsomes, all investigated PAs formed dehydropyrrolizidine metabolites with …
In addition, all diester PAs formed several dehydrogenation products, via the insertion of a second double bond in the necine base, i …
Metabolic Pattern of Hepatotoxic Pyrrolizidine Alkaloids in Liver Cells.
Geburek I, Rutz L, Gao L, Küpper JH, These A, Schrenk D. Geburek I, et al. Among authors: these a. Chem Res Toxicol. 2021 Apr 19;34(4):1101-1113. doi: 10.1021/acs.chemrestox.0c00507. Epub 2021 Mar 10. Chem Res Toxicol. 2021. PMID: 33719395
Contamination with 1,2-unsaturated pyrrolizidine alkaloids (PAs) is a serious problem for certain phytomedicines, foods, and animal feeds. ...Our data are in agreement with previously published cyto- and genotoxicity findings and suggests that the metabolic pattern may con …
Contamination with 1,2-unsaturated pyrrolizidine alkaloids (PAs) is a serious problem for certain phytomedicines, foods, and animal f …
40 results