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Page 1
Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development.
Hennegan J, Bryant AH, Griffiths L, Trigano M, Bartley OJM, Bartlett JJ, Minahan C, Abreu de Oliveira WA, Yutuc E, Ntikas S, Bartsocas CS, Markouri M, Antoniadou E, Laina I, Howell OW, Li M, Wang Y, Griffiths WJ, Lane EL, Lelos MJ, Theofilopoulos S. Hennegan J, et al. Among authors: theofilopoulos s. iScience. 2023 Dec 7;27(1):108670. doi: 10.1016/j.isci.2023.108670. eCollection 2024 Jan 19. iScience. 2023. PMID: 38155767 Free PMC article.
24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo.
Theofilopoulos S, Abreu de Oliveira WA, Yang S, Yutuc E, Saeed A, Abdel-Khalik J, Ullgren A, Cedazo-Minguez A, Björkhem I, Wang Y, Griffiths WJ, Arenas E. Theofilopoulos S, et al. J Biol Chem. 2019 Mar 15;294(11):4169-4176. doi: 10.1074/jbc.RA118.005639. Epub 2019 Jan 17. J Biol Chem. 2019. PMID: 30655290 Free PMC article.
Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma.
Griffiths WJ, Crick PJ, Meljon A, Theofilopoulos S, Abdel-Khalik J, Yutuc E, Parker JE, Kelly DE, Kelly SL, Arenas E, Wang Y. Griffiths WJ, et al. Among authors: theofilopoulos s. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb;1864(2):191-211. doi: 10.1016/j.bbalip.2018.11.006. Epub 2018 Nov 22. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30471425 Free PMC article.
The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson's Disease and Their Association With Disease State and Clinical Features.
Griffiths WJ, Abdel-Khalik J, Moore SF, Wijeyekoon RS, Crick PJ, Yutuc E, Farrell K, Breen DP, Williams-Gray CH, Theofilopoulos S, Arenas E, Trupp M, Barker RA, Wang Y. Griffiths WJ, et al. Among authors: theofilopoulos s. Front Aging Neurosci. 2021 Aug 30;13:685594. doi: 10.3389/fnagi.2021.685594. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34526889 Free PMC article.
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis.
Theofilopoulos S, Wang Y, Kitambi SS, Sacchetti P, Sousa KM, Bodin K, Kirk J, Saltó C, Gustafsson M, Toledo EM, Karu K, Gustafsson JÅ, Steffensen KR, Ernfors P, Sjövall J, Griffiths WJ, Arenas E. Theofilopoulos S, et al. Nat Chem Biol. 2013 Feb;9(2):126-33. doi: 10.1038/nchembio.1156. Epub 2012 Dec 23. Nat Chem Biol. 2013. PMID: 23292650
Analysis of bioactive oxysterols in newborn mouse brain by LC/MS.
Meljon A, Theofilopoulos S, Shackleton CH, Watson GL, Javitt NB, Knölker HJ, Saini R, Arenas E, Wang Y, Griffiths WJ. Meljon A, et al. Among authors: theofilopoulos s. J Lipid Res. 2012 Nov;53(11):2469-83. doi: 10.1194/jlr.D028233. Epub 2012 Aug 13. J Lipid Res. 2012. PMID: 22891291 Free PMC article.
Targeted lipidomic analysis of oxysterols in the embryonic central nervous system.
Wang Y, Sousa KM, Bodin K, Theofilopoulos S, Sacchetti P, Hornshaw M, Woffendin G, Karu K, Sjövall J, Arenas E, Griffiths WJ. Wang Y, et al. Among authors: theofilopoulos s. Mol Biosyst. 2009 May;5(5):529-41. doi: 10.1039/b819502a. Epub 2009 Mar 27. Mol Biosyst. 2009. PMID: 19381367 Free PMC article.
Cerebrospinal fluid steroidomics: are bioactive bile acids present in brain?
Ogundare M, Theofilopoulos S, Lockhart A, Hall LJ, Arenas E, Sjövall J, Brenton AG, Wang Y, Griffiths WJ. Ogundare M, et al. Among authors: theofilopoulos s. J Biol Chem. 2010 Feb 12;285(7):4666-79. doi: 10.1074/jbc.M109.086678. Epub 2009 Dec 7. J Biol Chem. 2010. PMID: 19996111 Free PMC article.
21 results