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Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.
Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA. Croker BA, et al. Among authors: theofilopoulos an. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15028-33. doi: 10.1073/pnas.0806619105. Epub 2008 Sep 19. Proc Natl Acad Sci U S A. 2008. PMID: 18806225 Free PMC article.
The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes.
Rimann I, Gonzalez-Quintial R, Baccala R, Kiosses WB, Teijaro JR, Parker CG, Li X, Beutler B, Kono DH, Theofilopoulos AN. Rimann I, et al. Among authors: theofilopoulos an. Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2200544119. doi: 10.1073/pnas.2200544119. Epub 2022 Mar 29. Proc Natl Acad Sci U S A. 2022. PMID: 35349343 Free PMC article.
Interferons as pathogenic effectors in autoimmunity.
Baccala R, Kono DH, Theofilopoulos AN. Baccala R, et al. Among authors: theofilopoulos an. Immunol Rev. 2005 Apr;204:9-26. doi: 10.1111/j.0105-2896.2005.00252.x. Immunol Rev. 2005. PMID: 15790347 Review.
Type I interferon is a therapeutic target for virus-induced lethal vascular damage.
Baccala R, Welch MJ, Gonzalez-Quintial R, Walsh KB, Teijaro JR, Nguyen A, Ng CT, Sullivan BM, Zarpellon A, Ruggeri ZM, de la Torre JC, Theofilopoulos AN, Oldstone MB. Baccala R, et al. Among authors: theofilopoulos an. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8925-30. doi: 10.1073/pnas.1408148111. Epub 2014 Jun 2. Proc Natl Acad Sci U S A. 2014. PMID: 24889626 Free PMC article.
261 results