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Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice.
van der Vorst EPC, Maas SL, Theodorou K, Peters LJF, Jin H, Rademakers T, Gijbels MJ, Rousch M, Jansen Y, Weber C, Lehrke M, Lebherz C, Yildiz D, Ludwig A, Bentzon JF, Biessen EAL, Donners MMPC. van der Vorst EPC, et al. Among authors: theodorou k. Front Cardiovasc Med. 2023 Jan 27;10:974918. doi: 10.3389/fcvm.2023.974918. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 36776254 Free PMC article.
Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis.
van der Vorst EP, Jeurissen M, Wolfs IM, Keijbeck A, Theodorou K, Wijnands E, Schurgers L, Weber S, Gijbels MJ, Hamers AA, Dreymueller D, Rose-John S, de Winther MP, Ludwig A, Saftig P, Biessen EA, Donners MM. van der Vorst EP, et al. Among authors: theodorou k. Am J Pathol. 2015 Apr;185(4):1145-55. doi: 10.1016/j.ajpath.2014.11.028. Epub 2015 Feb 7. Am J Pathol. 2015. PMID: 25659879 Free article.
Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression.
Theodorou K, van der Vorst EPC, Gijbels MJ, Wolfs IMJ, Jeurissen M, Theelen TL, Sluimer JC, Wijnands E, Cleutjens JP, Li Y, Jansen Y, Weber C, Ludwig A, Bentzon JF, Bartsch JW, Biessen EAL, Donners MMPC. Theodorou K, et al. Sci Rep. 2017 Sep 15;7(1):11670. doi: 10.1038/s41598-017-10549-x. Sci Rep. 2017. PMID: 28916789 Free PMC article.
High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.
van der Vorst EPC, Theodorou K, Wu Y, Hoeksema MA, Goossens P, Bursill CA, Aliyev T, Huitema LFA, Tas SW, Wolfs IMJ, Kuijpers MJE, Gijbels MJ, Schalkwijk CG, Koonen DPY, Abdollahi-Roodsaz S, McDaniels K, Wang CC, Leitges M, Lawrence T, Plat J, Van Eck M, Rye KA, Touqui L, de Winther MPJ, Biessen EAL, Donners MMPC. van der Vorst EPC, et al. Among authors: theodorou k. Cell Metab. 2017 Jan 10;25(1):197-207. doi: 10.1016/j.cmet.2016.10.013. Epub 2016 Nov 17. Cell Metab. 2017. PMID: 27866837 Free article.
Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.
Mentrup T, Theodorou K, Cabrera-Cabrera F, Helbig AO, Happ K, Gijbels M, Gradtke AC, Rabe B, Fukumori A, Steiner H, Tholey A, Fluhrer R, Donners M, Schröder B. Mentrup T, et al. Among authors: theodorou k. J Exp Med. 2019 Apr 1;216(4):807-830. doi: 10.1084/jem.20171438. Epub 2019 Feb 28. J Exp Med. 2019. PMID: 30819724 Free PMC article.
Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases.
Dreymueller D, Theodorou K, Donners M, Ludwig A. Dreymueller D, et al. Among authors: theodorou k. Mediators Inflamm. 2017;2017:9621724. doi: 10.1155/2017/9621724. Epub 2017 Feb 5. Mediators Inflamm. 2017. PMID: 28260841 Free PMC article. Review.
Endothelial Cell Metabolism in Atherosclerosis.
Theodorou K, Boon RA. Theodorou K, et al. Front Cell Dev Biol. 2018 Aug 7;6:82. doi: 10.3389/fcell.2018.00082. eCollection 2018. Front Cell Dev Biol. 2018. PMID: 30131957 Free PMC article. Review.
116 results