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Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA Desaturase.
J Med Chem. 2020 Sep 10;63(17):9773-9786. doi: 10.1021/acs.jmedchem.0c00899. Epub 2020 Aug 19.
J Med Chem. 2020.
PMID: 32787093
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D.
Theodoropoulos PC, et al.
Nat Chem Biol. 2016 Apr;12(4):218-25. doi: 10.1038/nchembio.2016. Epub 2016 Feb 1.
Nat Chem Biol. 2016.
PMID: 26829472
Free PMC article.
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Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer.
Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW.
Zhang L, et al. Among authors: theodoropoulos pc.
Sci Transl Med. 2016 Oct 19;8(361):361ra140. doi: 10.1126/scitranslmed.aaf8127.
Sci Transl Med. 2016.
PMID: 27798265
Free PMC article.
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A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins.
Theodoropoulos PC, Wang W, Budhipramono A, Thompson BM, Madhusudhan N, Mitsche MA, McDonald JG, De Brabander JK, Nijhawan D.
Theodoropoulos PC, et al.
J Am Chem Soc. 2020 Apr 1;142(13):6128-6138. doi: 10.1021/jacs.9b13407. Epub 2020 Mar 19.
J Am Chem Soc. 2020.
PMID: 32163279
Free PMC article.
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Essential requirement for nicastrin in marginal zone and B-1 B cell development.
Choi JH, Han J, Theodoropoulos PC, Zhong X, Wang J, Medler D, Ludwig S, Zhan X, Li X, Tang M, Gallagher T, Yu G, Beutler B.
Choi JH, et al. Among authors: theodoropoulos pc.
Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4894-4901. doi: 10.1073/pnas.1916645117. Epub 2020 Feb 18.
Proc Natl Acad Sci U S A. 2020.
PMID: 32071239
Free PMC article.
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