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Hydrogel-Guided, rAAV-Mediated IGF-I Overexpression Enables Long-Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large-Animal Full-Thickness Chondral Defect Model at One Year In Vivo.
Maihöfer J, Madry H, Rey-Rico A, Venkatesan JK, Goebel L, Schmitt G, Speicher-Mentges S, Cai X, Meng W, Zurakowski D, Menger MD, Laschke MW, Cucchiarini M. Maihöfer J, et al. Adv Mater. 2021 Apr;33(16):e2008451. doi: 10.1002/adma.202008451. Epub 2021 Mar 18. Adv Mater. 2021. PMID: 33734514
The regeneration of focal articular cartilage defects is complicated by the reduced quality of the repair tissue and the potential development of perifocal osteoarthritis (OA). Biomaterial-guided gene therapy may enhance cartilage repair by controlling the release o …
The regeneration of focal articular cartilage defects is complicated by the reduced quality of the repair tissue and the potential developme …
PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF-κB signaling.
Yang X, Wang Y, Lu P, Shen Y, Zhao X, Zhu Y, Jiang Z, Yang H, Pan H, Zhao L, Zhong Y, Wang J, Liang Z, Shen X, Lu D, Jiang S, Xu J, Wu H, Lu H, Jiang G, Zhu H. Yang X, et al. EMBO Rep. 2020 Nov 5;21(11):e49305. doi: 10.15252/embr.201949305. Epub 2020 Sep 14. EMBO Rep. 2020. PMID: 32924251 Free PMC article.
Here, by performing a genome-wide CRISPR-Cas9 knockout library screen, we identify phosphatidylethanolamine-binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein (RKIP), as a novel gene inducing HIV latency. Depletion of PEBP1 leads to the reactivation of H …
Here, by performing a genome-wide CRISPR-Cas9 knockout library screen, we identify phosphatidylethanolamine-binding protein 1 (PEBP1), also …