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JMX0207, a Niclosamide Derivative with Improved Pharmacokinetics, Suppresses Zika Virus Infection Both In Vitro and In Vivo.
Li Z, Xu J, Lang Y, Fan X, Kuo L, D'Brant L, Hu S, Samrat SK, Trudeau N, Tharappel AM, Rugenstein N, Koetzner CA, Zhang J, Chen H, Kramer LD, Butler D, Zhang QY, Zhou J, Li H. Li Z, et al. Among authors: tharappel am. ACS Infect Dis. 2020 Oct 9;6(10):2616-2628. doi: 10.1021/acsinfecdis.0c00217. Epub 2020 Sep 21. ACS Infect Dis. 2020. PMID: 32866370 Free PMC article.
Targeting Crucial Host Factors of SARS-CoV-2.
Tharappel AM, Samrat SK, Li Z, Li H. Tharappel AM, et al. ACS Infect Dis. 2020 Nov 13;6(11):2844-2865. doi: 10.1021/acsinfecdis.0c00456. Epub 2020 Oct 28. ACS Infect Dis. 2020. PMID: 33112126 Free PMC article. Review.
Small-molecule inhibitors for the Prp8 intein as antifungal agents.
Li Z, Tharappel AM, Xu J, Lang Y, Green CM, Zhang J, Lin Q, Chaturvedi S, Zhou J, Belfort M, Li H. Li Z, et al. Among authors: tharappel am. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2008815118. doi: 10.1073/pnas.2008815118. Proc Natl Acad Sci U S A. 2021. PMID: 33397721 Free PMC article.
Inteins as Drug Targets and Therapeutic Tools.
Tharappel AM, Li Z, Li H. Tharappel AM, et al. Front Mol Biosci. 2022 Feb 8;9:821146. doi: 10.3389/fmolb.2022.821146. eCollection 2022. Front Mol Biosci. 2022. PMID: 35211511 Free PMC article. Review.
Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.
Yang S, Xu M, Lee EM, Gorshkov K, Shiryaev SA, He S, Sun W, Cheng YS, Hu X, Tharappel AM, Lu B, Pinto A, Farhy C, Huang CT, Zhang Z, Zhu W, Wu Y, Zhou Y, Song G, Zhu H, Shamim K, Martínez-Romero C, García-Sastre A, Preston RA, Jayaweera DT, Huang R, Huang W, Xia M, Simeonov A, Ming G, Qiu X, Terskikh AV, Tang H, Song H, Zheng W. Yang S, et al. Among authors: tharappel am. Cell Discov. 2018 Jun 5;4:31. doi: 10.1038/s41421-018-0034-1. eCollection 2018. Cell Discov. 2018. PMID: 29872540 Free PMC article.
13 results