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Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function.
He D, Xu H, Zhang H, Tang R, Lan Y, Xing R, Li S, Christian E, Hou Y, Lorello P, Caldarone B, Ding J, Nguyen L, Dionne D, Thakore P, Schnell A, Huh JR, Rozenblatt-Rosen O, Regev A, Kuchroo VK. He D, et al. Among authors: thakore p. Immunity. 2022 Jan 11;55(1):159-173.e9. doi: 10.1016/j.immuni.2021.12.001. Epub 2022 Jan 3. Immunity. 2022. PMID: 34982959 Free PMC article.
Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses.
Wallrapp A, Burkett PR, Riesenfeld SJ, Kim SJ, Christian E, Abdulnour RE, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan P, Tsujikawa K, Xavier RJ, Chiu IM, Levy BD, Regev A, Kuchroo VK. Wallrapp A, et al. Among authors: thakore pi. Immunity. 2019 Oct 15;51(4):709-723.e6. doi: 10.1016/j.immuni.2019.09.005. Epub 2019 Oct 8. Immunity. 2019. PMID: 31604686 Free PMC article.
An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets.
Zhang H, Madi A, Yosef N, Chihara N, Awasthi A, Pot C, Lambden C, Srivastava A, Burkett PR, Nyman J, Christian E, Etminan Y, Lee A, Stroh H, Xia J, Karwacz K, Thakore PI, Acharya N, Schnell A, Wang C, Apetoh L, Rozenblatt-Rosen O, Anderson AC, Regev A, Kuchroo VK. Zhang H, et al. Cell Rep. 2020 Nov 24;33(8):108433. doi: 10.1016/j.celrep.2020.108433. Cell Rep. 2020. PMID: 33238123 Free PMC article.
Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity.
Schnell A, Huang L, Singer M, Singaraju A, Barilla RM, Regan BML, Bollhagen A, Thakore PI, Dionne D, Delorey TM, Pawlak M, Meyer Zu Horste G, Rozenblatt-Rosen O, Irizarry RA, Regev A, Kuchroo VK. Schnell A, et al. Cell. 2021 Dec 22;184(26):6281-6298.e23. doi: 10.1016/j.cell.2021.11.018. Epub 2021 Dec 6. Cell. 2021. PMID: 34875227 Free PMC article.
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.
Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef N. Wagner A, et al. Among authors: thakore p. Cell. 2021 Aug 5;184(16):4168-4185.e21. doi: 10.1016/j.cell.2021.05.045. Epub 2021 Jul 2. Cell. 2021. PMID: 34216539 Free PMC article.
Massively parallel phenotyping of coding variants in cancer with Perturb-seq.
Ursu O, Neal JT, Shea E, Thakore PI, Jerby-Arnon L, Nguyen L, Dionne D, Diaz C, Bauman J, Mosaad MM, Fagre C, Lo A, McSharry M, Giacomelli AO, Ly SH, Rozenblatt-Rosen O, Hahn WC, Aguirre AJ, Berger AH, Regev A, Boehm JS. Ursu O, et al. Nat Biotechnol. 2022 Jun;40(6):896-905. doi: 10.1038/s41587-021-01160-7. Epub 2022 Jan 20. Nat Biotechnol. 2022. PMID: 35058622
Author Correction: Massively parallel phenotyping of coding variants in cancer with Perturb-seq.
Ursu O, Neal JT, Shea E, Thakore PI, Jerby-Arnon L, Nguyen L, Dionne D, Diaz C, Bauman J, Mosaad MM, Fagre C, Lo A, McSharry M, Giacomelli AO, Ly SH, Rozenblatt-Rosen O, Hahn WC, Aguirre AJ, Berger AH, Regev A, Boehm JS. Ursu O, et al. Among authors: thakore pi. Nat Biotechnol. 2022 Nov;40(11):1691. doi: 10.1038/s41587-022-01495-9. Nat Biotechnol. 2022. PMID: 36258042 No abstract available.
Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing.
Simmons SK, Lithwick-Yanai G, Adiconis X, Oberstrass F, Iremadze N, Geiger-Schuller K, Thakore PI, Frangieh CJ, Barad O, Almogy G, Rozenblatt-Rosen O, Regev A, Lipson D, Levin JZ. Simmons SK, et al. Nat Biotechnol. 2023 Feb;41(2):204-211. doi: 10.1038/s41587-022-01452-6. Epub 2022 Sep 15. Nat Biotechnol. 2023. PMID: 36109685 Free PMC article.
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes.
Kiner E, Willie E, Vijaykumar B, Chowdhary K, Schmutz H, Chandler J, Schnell A, Thakore PI, LeGros G, Mostafavi S, Mathis D, Benoist C; Immunological Genome Project Consortium. Kiner E, et al. Nat Immunol. 2021 Feb;22(2):216-228. doi: 10.1038/s41590-020-00836-7. Epub 2021 Jan 18. Nat Immunol. 2021. PMID: 33462454 Free PMC article.
Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion.
Frangieh CJ, Melms JC, Thakore PI, Geiger-Schuller KR, Ho P, Luoma AM, Cleary B, Jerby-Arnon L, Malu S, Cuoco MS, Zhao M, Ager CR, Rogava M, Hovey L, Rotem A, Bernatchez C, Wucherpfennig KW, Johnson BE, Rozenblatt-Rosen O, Schadendorf D, Regev A, Izar B. Frangieh CJ, et al. Among authors: thakore pi. Nat Genet. 2021 Mar;53(3):332-341. doi: 10.1038/s41588-021-00779-1. Epub 2021 Mar 1. Nat Genet. 2021. PMID: 33649592 Free PMC article.
72 results